The brain activity induced by a sensory stimulus and measured by magnetoencephalography will be compared before and after exposure to millimeter waves. We hypothesize that brain activity is modified after exposure to millimeter waves. The neuromodulatory effects of millimeter waves may lead to future development on therapeutic management in anxiety and pain.
Several studies showed clinical efficacy of millimeter waves in pain management, with no side-effects. However, its mechanism of action is still partly unknown. Preclinical studies showed that the use of millimeter waves near highly-innervated areas stimulates subcutaneous receptors, even at low power. To achieve safe millimeter wave stimulation, we will use a bracelet (Remedee Labs) emitting millimeter waves, that has been developped for human use. It complies with radiofrequency exposure regulation (CE-marked). This study aims to provide a better understanding of the mechanism by which millimeter waves interact with somatosensory system in brain. For this purpose, the analysis of brain activity will focus on somatosensory responses elicited by electrical stimulation of the right thumb. Subjects will complete two sessions during which the brain activity will be recorded by magnetoencephalography (MEG) before, during and after the use of a bracelet emitting millimeter waves. Magnetoencephalography is chosen for its good temporal resolution, its sensitivity in the low frequencies and its accuracy to locate neural sources when matching with an Magnetic Resonance (MR) Imagery. It will allow us to study the shape and the delay of the somatosensory response in primary somatosensory cortex (SI) and secondary somatosensory cortex (SII) cortical areas of the brain.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
10
several blocks of somatosensory evoked potentials with or without Millimeter waves local exposure
Clinatec Cea/Chuga
Grenoble, France
Change in the somatosensory responses induced by the application of millimeter waves to the wrist
Statistically significant change in the evoked somatosensory magnetic activity time course
Time frame: 4 hours
Variation of the sympathovagal balance following the application of millimeter waves
Comparison of heart rate variability before and after application of millimeter waves
Time frame: 4 hours
Changes in resting brain activity during or after application of millimeter waves to the wrist
Characterization of oscillatory brain activity by frequency bands (power maps)
Time frame: 4 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.