This is an intervention study aiming to test the effectiveness of a vegan diet, My Plate with low purine choices, and amla fruits on uric acid and other cardiometabolic risk factors in individuals with high serum uric acid levels.
Ninety-two participants with hyperuricemia will be randomly assigned to one of these 4 diet interventions: (1) vegan, (2) vegan with amla fruits, (3) my plate-low purine, (4) my plate-low purine with amla fruits. During the 3 months intervention phase, participants will attend group lessons and individual nutrition counseling sessions to assist adherence to the diet. At baseline, end of 3 months, and 1 year, participants will be measured on uric acid and other cardiometabolic risk factors, and some nutritional markers. Amla fruits powder, and some foods encouraged in each dietary arm will be provided to enhance adherence during the 3 months intervention phase.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
102
Participants will attend group lessons and individual nutrition counseling to help them adopt a healthy vegan diet.
Participants will attend group lessons and individual nutrition counseling to help them adopt a balanced diet in accordance with my plate, and emphasis on choosing low purine options from the protein food groups.
Participants will be provided with powdered amla fruits, and will be instructed to take 3g per day.
Department of Nutritional Science, Fu-Jen Catholic University
New Taipei City, Taiwan
Uric acid
Serum uric acid
Time frame: 3 months
Body mass index
body mass index calculated from height and weight
Time frame: 3 months
Glucose metabolism
fasting glucose
Time frame: 3 months
Lipid profile
cholesterol
Time frame: 3 months
vitamin B12
serum vitamin B12
Time frame: 3 months
holostranscobalamin
serum holotranscobalamin
Time frame: 3 months
homocysteine
serum homocysteine
Time frame: 3 months
vitamin D
serum 25(OH)D
Time frame: 3 months
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