Factors and Prognostic Significance of Impaired Exercise Tolerance in Women Over 40 With Arterial Hypertension

Inclusion Criteria: * Age equal to or older than 40 years * Arterial hypertension (HA) diagnosed according to the 2018 European Society of Cardiology (ESC) guidelines of HA \[1\] * Current HA hospitalization Exclusion Criteria: * Severe hypertension * Diagnosis of heart failure or typical symptomatic heart failure * Left ventricular ejection fraction (LVEF) \<50% * Documented: hyperandrogenism, hyperestrogenism, insulin resistance, premature ovarian failure, polycystic ovary syndrome * Past myocardial infarction * Diagnosis of cardiomyopathy (hypertrophic, dilated, restrictive, peripartum, arrhythmogenic) * Lysosomal storage disorders * Stroke, transient ischemic attack, Intracerebral hemorrhage in medical history * Severe hyper- and hypothyroidism * Pregnancy and lactation * Chronic kidney disease (IV, V stadium according to National Kidney Foundation) and dialysis treatment * Documented neoplastic process * The patient's inability to cooperate and/or provide informed consent to participate in a research * Alcohol and drug abuse * Active autoimmune disease * Treatment using immunosuppressants, cytostatic drugs, glucocorticosteroids, or antiretroviral drugs * A history of bone marrow transplant or other organ transplant, treatment with blood products within the last 6 months * Active systemic infection * Hepatitis B virus (HBV), hepatitis C virus (HCV) or human immunodeficiency virus (HIV) carrier or positive for hepatitis B surface antigen (HBSAg) or antibodies to HCV * Surgery or serious injury within the last month * Patients who did not express their informed consent to participate in the study