Factors Influencing of Pulse Pressure Variation (PPV)

Southeast University, China189 enrolled

Overview

The investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.

PPV can be used to predict fluid responsiveness in patients with circulatory shock.However, it is affected by many factors, which leads to the decrease of the applicability of PPV in ICU.Therefore, the investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.

Study Type

OBSERVATIONAL

Enrollment

189

Conditions

Haemodynamics Fluid Responsiveness Pulse Pressure Variation

Interventions

Patients were ventilated with assist-control ventilation（A/C） mode at different tidal volumeDEVICE

Ventilation mode was set to assist-control volume ventilation with different tidal volume, respiratory frequency 15 times/min, PEEP 5 centimeter water column.

spontaneous breathing and no spontaneous breathingBEHAVIORAL

Data were recorded when patients had and did not have spontaneous breathing

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients requiring invasive mechanical ventilation * Acute circulatory failure,defined as:systolic blood pressure \<90 mmHg or blood pressure in patients with previous hypertension lower than the baseline value\> 40 mmHg; vasoactive drugs are required to maintain blood pressure (mean arterial pressure\> 65 mmHg); with or without signs of hypoperfusion (oliguria\<0.5ml.kg-1.h-1 for at least 2 hours; arterial blood lactic acid\>2.5mmol.L-1; skin mottling) Exclusion Criteria: * The age of the patient is less than 18 years old or more than 80 years old * Refuse to sign the informed consent to join the group * Atrial fibrillation and other arrhythmias that seriously affect the output per beat; * With pregnancy * Other situations where the clinician believes that the patient is not suitable for inclusion in the study

Locations (1)

Ling Liu

Nanjing, Jiangsu, China

Outcomes

Primary Outcomes

cardiac output(CO)

The measurement of cardiac output(CO);

Time frame: 1 day

Secondary Outcomes

measurement of Hemodynamic variables from the monitor;

The investigators record the hemodynamic variables from the monitor MAP and CVP

Time frame: 1 day

measurement of Pulse pressure variation（PPV）from monitor;

Pulse pressure variation (PPV)(percent) ,whic is calculated from the systolic and diastolic blood pressure,can be read from the monitor directly.

Time frame: Research period

measurement of airway pressure variables from ventilator

The investigators record the airway pressure variables during the inspiration and expiration from the ventilator

Time frame: 1 day

P 0.1

airway occlusion pressure at 100 milliseconds after the onset of inspiration (P0.1)(cmH2O)

Time frame: 1 day

Pocc

delta change of airway pressure during expiratory occlusion in different interventions.

Time frame: 1 day

Data from ClinicalTrials.gov

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