In the period from June 2021 to June 2022, a prospective clinical study will be conducted in the Republic of Kazakhstan with economy class passengers traveling by plane with a minimum flight period of 5-7 flight hours in the territory of the Republic of Kazakhstan.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
50
Citicoline 500 mg (Vitaae®) per os
Cytochrome10 mg per os
Sodium Chloride (NaCl) 2.6 g. per os
Urine Specific Gravity
Urine Specific Gravity test
Time frame: 24 hours before the flight
SpO2 level
Pulse oximetry
Time frame: 24 hours before the flight
Ultrasound examination
Ultrasound examination of the veins of the lower limbs
Time frame: 24 hours before the flight
The Liverpool Jet Lag questionnaire
Changes from normal (0 to 5) while jetlag rating was recorded on a scale from 0 = insignificant jetlag to 10 = severe jetlag
Time frame: 24 hours before the flight
Lake Louise Acute Mountain Sickness Assessment System
Mild acute mountain sicknessas 3-5 points, moderate acute mountain sickness as 6-9 points, and severe acute mountain sickness as 10-12 points
Time frame: 24 hours before the flight
Neuropsychological tests (Trail Making Test, Wechsler Memory Scale - IV, Free recall
Word, color, and color-word T-Scores of 40 or less are considered "low." Word, color, and color-word T-Scores above 40 or are considered "normal." In order for one score to be considered "higher" or "lower" than another, a 10 point or greater T score difference is required.
Time frame: 24 hours after the flight
The Liverpool Jet Lag questionnaire (LJLQ)
Changes from normal (0 to 5) while jetlag rating was recorded on a scale from 0 = insignificant jetlag to 10 = severe jetlag
Time frame: 24 hours after the flight
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Potassium Chloride 1.5 g per os
Sodium Citrate 2.90 g per os
Dextrose 13.5 g per os
Domperidone 1 tablet per os
3-4 capsules per os
Acetylsalicylic acid 150 mg per os
magnesium hydroxide 30 mg per os
1 capsule per os.
Melatonin 5 mg per os.
Lake Louise Acute Mountain Sickness Assessment System
Mild acute mountain sicknessas 3-5 points, moderate acute mountain sickness as 6-9 points, and severe acute mountain sickness as 10-12 points
Time frame: 24 hours after the flight
The Stroop Test
Word, color, and color-word T-Scores of 40 or less are considered "low." Word, color, and color-word T-Scores above 40 or are considered "normal." In order for one score to be considered "higher" or "lower" than another, a 10 point or greater T score difference is required.
Time frame: 24 hours after the flight
Urine Specific Gravity
Urine Specific Gravity test
Time frame: 24 hours after the flight
SpO2 level
Pulse oximetry
Time frame: 24 hours before the flight