Microarchitecture of Vitreoretinal Contact

The S.N. Fyodorov Eye Microsurgery State Institution20 enrolled

Overview

Investigation of the vitreoretinal contact microarchitecture in the macular and paramacular zones of the human retina.

Purpose: to study the features of the macular ILM, to study the features of the preretinal structures of the vitreous body of the Central retinal region, morphofunctional features of preretinal hyalocytes, and the mechanism of vitreoretinal adhesion. Study Protocol: examination of donor human eyes obtained from an eye Bank after sampling material for corneal transplantation. Research method: scanning electron microscopy (SEM) of the central retina (macular and paramacular zone): ILM, preretinal vitreous. Scientific hypothesis: vitreoretinal adhesion is provided not by laminin and fibronectin, but by the interweaving of vitreous collagen fibers between the epiretinal vitreous (more firmly fixed to the retinal surface) and the cortical vitreous. Expected results: determination of ILM thickness in the macular zone, microanatomy of preretinal vitreous strutcures, and possible mechanism of vitreoretinal adhesion, establishing the possibility of intravital synthesis of collagen fibers synthesis in the adult vitreous.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Vitreoretinal Detachment Vitreo-Retinal Adhesion

Interventions

scanning electron microscopyOTHER

scanning electron microscopy of the сentral retina and preretinal structures

Eligibility

Sex: ALLMin age: 35 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * eyes from donors without concomitant multiple organ pathology and ophthalmic pathology Exclusion Criteria: * eye injury, age over 45 years, concomitant multiple organ pathology, previous eye diseases

Locations (1)

S.N. Fedorov Nmrc "Mntk "Eye Microsurgery"

Moscow, Russia

Outcomes

Primary Outcomes

the ILM thickness in the macular zone (foveola)

the ILM thickness in the macular zone (foveola) in mkm by scanning electron microscopy data

Time frame: within 3 days after receiving the cadaver eyes

superficial microstructure of ILM

by scanning electron microscopy data

Time frame: within 3 days after receiving the cadaver eyes

features of the structural microarchitecture of the preretinal vitreous in the macular zone

by scanning electron microscopy data

Time frame: within 3 days after receiving the cadaver eyes

morphofunctional features of preretinal hyalocytes.

by scanning electron microscopy data

Time frame: within 3 days after receiving the cadaver eyes

Data from ClinicalTrials.gov

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