The purpose of this study is to demonstrate that addition of the Monocyte Width Distribution (MDW) parameter to current standard of care improves a clinician's ability to recognize sepsis in the Emergency Department, resulting in earlier decision to administer antibiotics from time of ED presentation for sepsis patients (simulated primary endpoint), with concomitant reductions in length of stay and in-hospital mortality for those patients (secondary endpoints).
The objective of this study is to develop a method for identifying sepsis patients from electronic health records (EHR) based on Sepsis-2 criteria. Sepsis patients will be identified using a Sepsis Definition which includes meeting SIRS score of ≥2 within 12 hours of ED presentation and any microbial testing ordered within 24 hours of ED presentation. The patient will be enrolled if it meets the Sepsis Definition and additional EMR data elements will be extracted to complete case report form. Furthermore, objectives include to confirm the clinical validity and performance of MDW in a control population of sepsis patients where MDW is measured but not reported to physicians. This study is an observational study which will simulate the decision impact of MDW on sepsis identification and patient management.
Study Type
OBSERVATIONAL
Enrollment
198
MDW measurement used to detect sepsis. Results will not be used to manage patients.
Hackensack University Medical Center
Hackensack, New Jersey, United States
Potential reduction of Time to Antibiotics
MDW's ability to reduce time to first antibiotics ordered by physician (decision to treat)-Simulated
Time frame: Within 12 hours from presentation to the emergency department
Performance
MDW's ability to identify Sepsis vs Non-Sepsis when using a Sepsis electronic medical record definition
Time frame: Within 12 hours from presentation to the emergency department
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