Recent studies suggest that patients with an history of trauma may represent a specific subtype of anorexia nervosa (AM) underlined by specific neurobiological and psychopathological mechanisms. Thus, AM-T subjects would manifest cognitive (specific difficulties in executive functions), emotional (emotional disruption, impulsivity, etc.) and neurobiological (secretion of kynurenine and neurokinins in the face of stress) caracteristics different from those of AM subjects.
We will recruit a total of 100 patients with a diagnosis of anorexia nervosa in the university hospital of Montpellier : 50 patients with an history of psychological trauma and 50 patients without any history of psychological trauma Participation consists of a half-day visit. Patients will perform clinical and neuropsychological assessments and an exposition test. During this test, participants will be exposed, for 7 minutes, to neutral, positive or negative emotional photos. Heart rate variability will be determined through a Biopac MP160 before, during and after this event. Saliva samples to measure kynurenin, tryptophan, substance P and neurokinin-1 will be collected before and directly after the test.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
4
During this test (7 minutes) participants will be exposed to photos evoking positive or negative emotions (anger, disgust, sadness and fear) interspersed with emotionally neutral photos. The test sequence is composed of 3 blocks as follows: * 12 photos evoking positive emotions (2 min) * Pause of 30 seconds (white screen) * 12 photos presenting a neutral emotional valence (2 min) * Pause of 30 seconds (white screen) * 12 photos evoking negative emotions (2min) In each block, photos will be selected and presented to the participant in a randomized and sequential manner. In total, 30 photos will be presented in 7 minutes to each participant (10 seconds per photo). The participant must be at rest in front of the computer screen during these 7 minutes with optimal visibility. The photos will be presented sequentially using software (E-Prime or Visual Basic 6.0). During this exposure test, a heart rate recording will be made using a BIOPAC MP160 recording system.
University Hospital, Montpellier
Montpellier, France
Changes in high frequency heart variability (HF-HRV) across the exposition test (before, during and after)
We aim to investigate if AM-T patients present changes in HF-HRV across exposition test compared to AM-C patients, measured by Biopac MP160
Time frame: inclusion visit
Changes in low frequency heart variability (LF-HRV) across the exposition test (before, during and after)
We aim to investigate if AM-T patients present changes in LF-HRV across exposition test compared to AM-C patients, measured by Biopac MP160
Time frame: inclusion visit
Changes in very low frequency heart variability (VLF-HRV) across the exposition test (before, during and after)
We aim to investigate if AM-T patients present changes in VLF-HRV across exposition test compared to AM-C patients, measured by Biopac MP160
Time frame: inclusion visit
Changes in the highest peak of the high frequency (HFhz) across the exposition test (before, during and after)
We aim to investigate if AM-T patients present changes in HFhz across exposition test compared to AM-C patients, measured by Biopac MP160
Time frame: inclusion visit
Changes in the interval between R peaks (R-R across the exposition test (before, during and after)
We aim to investigate if AM-T patients present R-R changes across exposition test compared to AM-C patients, measured by Biopac MP160
Time frame: inclusion visit
Changes in the R-R interval standard difference (STD-RR) across the exposition test (before, during and after)
We aim to investigate if AM-T patients present STD-RR changes across exposition test compared to AM-C patients, measured by Biopac MP160
Time frame: inclusion visit
Changes in the root mean successive squared differences of the R-R interval (RMSSD). across the exposition test (before, during and after)
We aim to investigate if AM-T patients present RMSSD changes across exposition test compared to AM-C patients, measured by Biopac MP160
Time frame: inclusion visit
Score to the Difficulties in Emotion Regulation Scale
We aim to assess the link between emotional regulation and psychological trauma in AN. DERS is a self-assessment scale measuring emotion dysregulation. The original DERS includes 36 items scored 1-5 where 1 is almost never, 2 is sometimes, 3 is about half the time, 4 is most of the time, and 5 is almost always. Of the 36 items, 11 are reverse scored. The DERS-36 yields a total score as well as six subscales where higher scores indicate more difficulties.
Time frame: inclusion visit
Score to the Beck depression inventory II
We aim to assess the link between eating symptomatology and psychological trauma in AN. The BDI-II is a self-administered questionnaire assessing the severity of depressive symptoms in 21 items. Each item is rated on a 4-points Likert scale ranging from 0 to 3. The total score varies between 0 and 63. higher scores mean more depressive symptoms
Time frame: inclusion visit
Score to the Eating Disorder Questionnaire
We aim to assess the link betxeen eating symptomatology and psychological trauma in AN. self-administered questionnaire assessing the intensity of eating symptoms over the past 28 days. A total score as well as 4 sub-scores (restriction, diet, weight, shape) varying from 0 to 6 are obtained.Higher scores mean higher eating concerns
Time frame: inclusion visit
Score to the Eating Disorder Inventory
We aim to assess the link between eating symptomatology and psychological trauma in AN. The EDI-2 is a 91-item self-report questionnaire assessing cognitive, emotional, and behavioral symptoms of eating disorders. It rates from 0 to 273. Higher scores means severe symptoms
Time frame: inclusion visit
Score to the Childhood trauma questionnaire
Time frame: inclusion visit
Score to the PTSD Checklist for DSM-5
Time frame: inclusion visit
Score to the Wisconson Card Sorting Test
We aim to assess the link between mental flexibility, working memory, inhibition and psychological trauma in AN
Time frame: inclusion visit
Score to the Stroop Test
We aim to assess the link between mental flexibility, working memory, inhibition and psychological trauma in AN
Time frame: inclusion visit
Score to the Delay Discounting Test
We aim to assess the link between decision making and psychological trauma in AN
Time frame: inclusion visit
Score to the Trail Making Test
We aim to assess the link between mental flexibility, visio-spatial attention, processing speed and psychological trauma in AN
Time frame: inclusion visit
Changes in salivary tryptophan
study changes in salivary tryptophan before and after exposition test
Time frame: inclusion visit
Changes in salivary kynurenine
study changes in salivary kynurenine before and after exposition test
Time frame: inclusion visit
Changes in salivary P substance
study changes in salivary P substance before and after exposition test
Time frame: inclusion visit
Changes in salivary neurokinin-1
study changes in salivary neurokinin-1before and after exposition test
Time frame: inclusion visit
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