60% of patients with diffuse large B cell lymphoma are healed after first-line treatment which whatever the age. For the remaining 40% of patients (relapses and primary refractories): * 38% of patients will be cured with a 2nd line including an autologous haematopoietic cell transplantation for those under 65 years. * for older patients who are not eligible for a autograft: only 70% of patients will be able to receive 2nd line treatment with rates response less than 50%. * the survival rate in patients receiving 3rd line treatment or more is 15% at 2 years. Actually, no standard of chemotherapy is offered to relapsed or refractory patients after 2 therapeutic lines. Subsequent lines lead to hospitalizations for infectious complications or transfusions without clear clinical benefit with often an impacted quality of life. Palliative care is rarely offered as part of the treatment overall load.
Study Type
OBSERVATIONAL
Enrollment
180
determination of a prognostic score with 3 clinical and 5 biological parameters.
Clinique Victor Hugo / Centre Jean Bernard
Le Mans, France
RECRUITINGCentre d'Oncologie de Gentilly
Nancy, France
NOT_YET_RECRUITINGOverall survival
Time between the date of relapse or no response observed (after 2 lines of chemotherapy in young patients and one line for elderly patients) and the date of death regardless of the cause.
Time frame: 5 years
Median response time after each line
Time between the date when the first response criterion is observed (partial or complete response) and the date when the recurrence or progression is objectively documented
Time frame: 5 years
Event-free survival since diagnosis and after each line of treatment received
Time between the date of diagnosis and the date of the first event observed, then between the date of the first administration of each line of treatment administered and the date of onset of the first event observed.
Time frame: 5 years
the intensity dose of chemotherapy received
Total amount of chemotherapy administered relative to the theoretical dose calculated according to the patient's body surface area.
Time frame: 6 month
the Cumulative Illness Rating Scale for comorbidities score in patients over 65 years old
The cumulative illness rating scale for comorbidity score in elderly patients will be calculated according to the table proposed by Salvi et al. in 2008 (values :0 to 56; higher scores mean a worse outcome).
Time frame: 6 month
Katell LE DU, MD
CONTACT
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