Desflurane and Postoperative Sleep Quality in Patients Undergoing Elective Breast Surgery

Zhongnan Hospital118 enrolled

Overview

This study intends to investigate the effects of desflurane on postoperative sleep quality to guide perioperative patient management.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

118

Conditions

Desflurane Propofol Postoperative Sleep PSQI Breast Tumor

Interventions

Desflurane InhalationDRUG

Subjects were randomized in a 1:1 ratio to undergo breast surgery under maintenance of anesthesia with the classical intravenous anesthetic drug propofol (reference group) or the inhaled anesthetic drug desflurane (test group).

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Undergoing elective breast surgery 2. Age 18-75 years old 3. ASA-PS grade I or II 4. Those who voluntarily participate in the research and sign the informed consent Exclusion Criteria: 1. Cognitive impairment (MMSE \<27) before the operation 2. The patients received adjuvant chemotherapy before the operation 3. At present, they are taking psychoactive, opioid, anti-anxiety, and hypnotic drugs 4. Known or treated patients with obstructive sleep apnea 5. Patients with other cancers

Locations (1)

Zhongnan Hospital of Wuhan University

Wuhan, Hubei, China

Outcomes

Primary Outcomes

Pittsburgh sleep quality index

Time frame: Postoperative 3rd day

Secondary Outcomes

Pittsburgh sleep quality index

Time frame: Postoperative 7th, and 30th days

Total sleep time (TST), Rapid eye movement time (REM), Wakefulness after sleep onset (WASO)

Fitbit Charge 2™ objectively measured

Time frame: Postoperative 1st, 2nd, and 3rd days

Self-Rating Anxiety Scale Scores

Time frame: Postoperative 3rd, 7th, and 30th days

Self-Rating Depression Scale Scores

Time frame: Postoperative 3rd, 7th and 30th days

Visual analogue scale scores

Time frame: Postoperative 3rd, 7th and 30th days

Flurbiprofen dose

Time frame: Postoperative 1st, 2nd, and 3rd days

Recovery time and quality (steward scores)

Time frame: Up to 2 hours after operation

Data from ClinicalTrials.gov

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