Evaluating the Safety and Effectiveness of the Laminar Left Atrial Appendage Closure System

Inclusion Criteria: * 1\. Subject must have a documented history of paroxysmal, persistent or permanent nonvalvular atrial fibrillation (AF). * 2\. Subject must be ≥18 years of age. * 3\. Subject has a calculated CHA2DS2-VASc score of 2 or greater. * 4\. Subject must be clinically stable on warfarin (or other anticoagulant) therapy for a minimum of three months. * 5\. Subject must have at least two International Normalized Ratios (INRs); 2-3, if on Warfarin. * 6\. Subject is eligible for the defined protocol pharmacologic regimen of anticoagulation and antiplatelet therapy. Exclusion Criteria: * 1\. Subject who requires anticoagulation for a condition other than AF. * 2\. Subject with a New York Heart Association (NYHA) classification equal to IV. * 3\. Subject with a history of or implanted atrial septal defect (ASD) device or patent foramen ovale (PFO) device that would interfere with the investigational device placement. * 4\. Subject with valvular disease.