Evaluation of the physiological and clinical effects of the biofeedback training with patients suffering from somatoform disorders, depending on their neurovegetative profile related to a visceral-brain decoupling.
Somatoform disorders \[SD\] are defined as physiological function or organ disturbances unexplained by a specific diagnosis criterion. Some approaches have recently defended the idea of common factors of vulnerability behind the large variability of the clinical symptoms regarding the SD. In this context, the lead of the neurovegetative disturbances started receiving attention following some studies that suggested the autonomic nervous system \[ANS\] disturbances concerning a somatoform disorder, independently of its form. Two different neurovegetative endophenotypes (individual autonomic profiles) were highlighted: a functional neurovegetative profile (high vagal tone) and a dysfunctional neurovegetative profile (low vagal tone). A dysfunctional neurovegetative profile could be accompanied by a chronic decoupling in the brain-visceral axis according as the ANS is considered as a bidirectional communication system linked the central nervous system \[CNS\] and the viscera. Depending on the types of the neurovegetative profiles, different degrees of cognitive-emotional vulnerability and a higher or a lower level of acceptance of the illness could be supposed. Finally, recent findings defend the idea of the traumatic experiences as a determining factor to develop a SD. In accordance to the last notions regarding the SD, some therapeutic approaches could be interesting specifically techniques focusing on the vagal nerve. In this context, biofeedback \[BFB\] could provide a powerful method to restore the clinical and physiological impairments. As a consequence, the main objective is to evaluate the physiological and clinical effects of the BFB training with patients suffering from SD: Irritable Bowel Syndrome \[IBS\] or Psychogenic Non Epileptic Seizure \[PNES\]. The investigators make the prediction that the patients will be more or less responding to the biofeedback depending on their neurovegetative profile. A clustering will be performed in advance to identify the patients having a dysfunctional neurovegetative profile and patients having a functional neurovegetative profile. It will also permit to the investigators to confirm the hypothesis about the existence of two neurovegetative profiles related to a visceral-brain decoupling concerning the SD, independently of its form. To attest to it, 2 types of somatoform disorders will be analyzed: the irritable bowel syndrome manifesting by peripheral symptoms and the psychogenic non-epileptic seizures manifesting by central symptoms. Then the investigators will carry out a psycho-social exploration to demonstrate a higher cognitive-emotional vulnerability and a higher traumatic event incidence in this particular population, depending on their autonomic profiles.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
46
BFB consists of a physiological recording used as a visual physiological feedback that can teach us how to control our physiology, which is naturally unconscious and uncontrollable. The BFB focused on the heart rate variability (HRV-BFB) could regulate the autonomic nervous system (vagal tone and sympathetic-parasympathetic balance) and the emotional state. The HRV BFB has received several clinical and experimental confirmations as a physiological remediation method. It is an innovative and non-pharmacological therapy frequently used to relieve stress.
University Hospital, Grenoble Alpes
Grenoble, Isère, France
High frequency [HF] (0.15-0.40 Hz)
High frequency (0.15-0.40 Hz), frequency-domain parameter HF will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Day 1 (T1)
High frequency [HF] (0.15-0.40 Hz)
High frequency (0.15-0.40 Hz), frequency-domain parameter HF will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 25 days from T1 (T2)
High frequency [HF] (0.15-0.40 Hz)
High frequency (0.15-0.40 Hz), frequency-domain parameter HF will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 52 days from T1 (T3)
Root mean square of successive RR interval differences [RMSSD]
Root mean square of successive RR interval differences, temporal-domain parameter RMSSD will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Day 1 (T1)
Root mean square of successive RR interval differences [RMSSD]
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Root mean square of successive RR interval differences, temporal-domain parameter RMSSD will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 25 days from T1 (T2)
Root mean square of successive RR interval differences [RMSSD]
Root mean square of successive RR interval differences, temporal-domain parameter RMSSD will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 52 days from T1 (T3)
Low frequency [LF] (0.04-0.15 Hz)
Low frequency (0.04-0.15 Hz), frequency-domain parameter LF will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Day 1 (T1)
Low frequency [LF] (0.04-0.15 Hz)
Low frequency (0.04-0.15 Hz), frequency-domain parameter LF will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 25 days from T1 (T2)
Low frequency [LF] (0.04-0.15 Hz)
Low frequency (0.04-0.15 Hz), frequency-domain parameter LF will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 52 days from T1 (T3)
Low frequency [LF] 0.1 Hertz (0.075-0.108Hz)
Spectral power of the low-frequency 0.1Hz band (0.075-0.108Hz), frequency-domain parameter LF-0.1Hz will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Day 1 (T1)
Low frequency [LF] 0.1 Hertz (0.075-0.108Hz)
Spectral power of the low-frequency 0.1Hz band (0.075-0.108Hz), frequency-domain parameter LF-0.1Hz will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 25 days from T1 (T2)
Low frequency [LF] 0.1 Hertz (0.075-0.108Hz)
Spectral power of the low-frequency 0.1Hz band (0.075-0.108Hz), frequency-domain parameter LF-0.1Hz will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 52 days from T1 (T3)
Total power (0-0.40 Hz)
Total power of the 0-0.40 Hertz band, frequency-domain parameter Total power will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Day 1 (T1)
Total power (0-0.40 Hz)
Total power of the 0-0.40 Hertz band, frequency-domain parameter Total power will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 25 days from T1 (T2)
Total power (0-0.40 Hz)
Total power of the 0-0.40 Hertz band, frequency-domain parameter Total power will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 52 days from T1 (T3)
Ratio Low frequency / High frequency [LF / HF]
Ratio of LF to HF power, frequency-domain parameter LF/HF will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Day 1 (T1)
Ratio Low frequency / High frequency [LF / HF]
Ratio of LF to HF power, frequency-domain parameter LF/HF will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 25 days from T1 (T2)
Ratio Low frequency / High frequency [LF / HF]
Ratio of LF to HF power, frequency-domain parameter LF/HF will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 52 days from T1 (T3)
Standard deviation of all NN intervals [SDNN]
Standard deviation of all NN intervals, temporal-domain parameter SDNN will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Day 1 (T1)
Standard deviation of all NN intervals [SDNN]
Standard deviation of all NN intervals, temporal-domain parameter SDNN will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 25 days from T1 (T2)
Standard deviation of all NN intervals [SDNN]
Standard deviation of all NN intervals, temporal-domain parameter SDNN will be measured using the electrocardiogram \[ECG\]: ECG data will be recorded using 3 single use and adhesive electrodes placed on the inner side of the right wrist, on the right shoulder and on the left side in accordance with the DII standard position (Einthoven). Physiological data recorded are related to the heart rate variability \[HRV\].
Time frame: Up to 52 days from T1 (T3)
Skin conductance responses [SCR] frequency
Skin conductance responses \[SCR\] frequency : number of the spontaneous galvanic skin responses by periods SCR will be measured using the Galvanic skin responses \[GSR\]: GSR data will be recorded using 2 skin sensors placed on the third phalanx of the forefinger and of the middle finger of the left hand. Physiological data recorded are related to the cholinergic sympathetic activity (tonic GSR / phasic GSR).
Time frame: Day 1 (T1)
Skin conductance responses [SCR] frequency
Skin conductance responses \[SCR\] frequency : number of the spontaneous galvanic skin responses by periods SCR will be measured using the Galvanic skin responses \[GSR\]: GSR data will be recorded using 2 skin sensors placed on the third phalanx of the forefinger and of the middle finger of the left hand. Physiological data recorded are related to the cholinergic sympathetic activity (tonic GSR / phasic GSR).
Time frame: Up to 25 days from T1 (T2)
Skin conductance responses [SCR] frequency
Skin conductance responses \[SCR\] frequency : number of the spontaneous galvanic skin responses by periods SCR will be measured using the Galvanic skin responses \[GSR\]: GSR data will be recorded using 2 skin sensors placed on the third phalanx of the forefinger and of the middle finger of the left hand. Physiological data recorded are related to the cholinergic sympathetic activity (tonic GSR / phasic GSR).
Time frame: Up to 52 days from T1 (T3)
Skin conductance responses [SCR] amplitude
Skin conductance responses amplitude: amplitude of the spontaneous galvanic skin responses by periods SCR will be measured using the Galvanic skin responses \[GSR\]: GSR data will be recorded using 2 skin sensors placed on the third phalanx of the forefinger and of the middle finger of the left hand. Physiological data recorded are related to the cholinergic sympathetic activity (tonic GSR / phasic GSR).
Time frame: Day 1 (T1)
Skin conductance responses [SCR] amplitude
Skin conductance responses amplitude: amplitude of the spontaneous galvanic skin responses by periods SCR will be measured using the Galvanic skin responses \[GSR\]: GSR data will be recorded using 2 skin sensors placed on the third phalanx of the forefinger and of the middle finger of the left hand. Physiological data recorded are related to the cholinergic sympathetic activity (tonic GSR / phasic GSR).
Time frame: Up to 25 days from T1 (T2)
Skin conductance responses [SCR] amplitude
Skin conductance responses amplitude: amplitude of the spontaneous galvanic skin responses by periods SCR will be measured using the Galvanic skin responses \[GSR\]: GSR data will be recorded using 2 skin sensors placed on the third phalanx of the forefinger and of the middle finger of the left hand. Physiological data recorded are related to the cholinergic sympathetic activity (tonic GSR / phasic GSR).
Time frame: Up to 52 days from T1 (T3)
Integrated skin conductance responses [ISCR]
Integrated skin conductance responses \[ISCR\]: area of the galvanic skin responses identified on the signal ISCR will be measured using the Galvanic skin responses \[GSR\]: GSR data will be recorded using 2 skin sensors placed on the third phalanx of the forefinger and of the middle finger of the left hand. Physiological data recorded are related to the cholinergic sympathetic activity (tonic GSR / phasic GSR).
Time frame: Day 1 (T1)
Integrated skin conductance responses [ISCR]
Integrated skin conductance responses \[ISCR\]: area of the galvanic skin responses identified on the signal ISCR will be measured using the Galvanic skin responses \[GSR\]: GSR data will be recorded using 2 skin sensors placed on the third phalanx of the forefinger and of the middle finger of the left hand. Physiological data recorded are related to the cholinergic sympathetic activity (tonic GSR / phasic GSR).
Time frame: Up to 25 days from T1 (T2)
Integrated skin conductance responses [ISCR]
Integrated skin conductance responses \[ISCR\]: area of the galvanic skin responses identified on the signal ISCR will be measured using the Galvanic skin responses \[GSR\]: GSR data will be recorded using 2 skin sensors placed on the third phalanx of the forefinger and of the middle finger of the left hand. Physiological data recorded are related to the cholinergic sympathetic activity (tonic GSR / phasic GSR).
Time frame: Up to 52 days from T1 (T3)
Pulsatility index variation [PI]
Pulsatility index variation \[PI\] : transit time flow PI will be measured using the Photoplethysmography \[PPG\]: PPG data will be recorded using a finger sensor. Physiological data recorded are related to the adrenergic sympathetic tone and allowing a record of the blood pulse waves associated with the heart rate.
Time frame: Day 1 (T1)
Pulsatility index variation [PI]
Pulsatility index variation \[PI\] : transit time flow PI will be measured using the Photoplethysmography \[PPG\]: PPG data will be recorded using a finger sensor. Physiological data recorded are related to the adrenergic sympathetic tone and allowing a record of the blood pulse waves associated with the heart rate.
Time frame: Up to 25 days from T1 (T2)
Pulsatility index variation [PI]
Pulsatility index variation \[PI\] : transit time flow PI will be measured using the Photoplethysmography \[PPG\]: PPG data will be recorded using a finger sensor. Physiological data recorded are related to the adrenergic sympathetic tone and allowing a record of the blood pulse waves associated with the heart rate.
Time frame: Up to 52 days from T1 (T3)
Breathing rate
Breathing rate by cycles per minute The breathing rate will be measured using a breathing belt.
Time frame: Day 1 (T1)
Breathing rate
Breathing rate by cycles per minute The breathing rate will be measured using a breathing belt.
Time frame: Up to 25 days from T1 (T2)
Breathing rate
Breathing rate by cycles per minute The breathing rate will be measured using a breathing belt.
Time frame: Up to 52 days from T1 (T3)
Dominant power (0-0.15Hz)
Dominant power of the 0-0.15 Hertz band, frequency-domain parameter Dominant power will be measured using the electrogastrogram \[EGG\]: EGG data will be recorded using 6 single use and adhesive electrodes placed on the skin of the abdomen.
Time frame: Day 1 (T1)
Dominant power (0-0.15Hz)
Dominant power of the 0-0.15 Hertz band, frequency-domain parameter Dominant power will be measured using the electrogastrogram \[EGG\]: EGG data will be recorded using 6 single use and adhesive electrodes placed on the skin of the abdomen.
Time frame: Up to 25 days from T1 (T2)
Dominant power (0-0.15Hz)
Dominant power of the 0-0.15 Hertz band, frequency-domain parameter Dominant power will be measured using the electrogastrogram \[EGG\]: EGG data will be recorded using 6 single use and adhesive electrodes placed on the skin of the abdomen.
Time frame: Up to 52 days from T1 (T3)
Total power (0-0.15Hz)
Total power of the 0-0.15 Hertz band, frequency-domain parameter Total power will be measured using the electrogastrogram \[EGG\]: EGG data will be recorded using 6 single use and adhesive electrodes placed on the skin of the abdomen.
Time frame: Day 1 (T1)
Total power (0-0.15Hz)
Total power of the 0-0.15 Hertz band, frequency-domain parameter Total power will be measured using the electrogastrogram \[EGG\]: EGG data will be recorded using 6 single use and adhesive electrodes placed on the skin of the abdomen.
Time frame: Up to 25 days from T1 (T2)
Total power (0-0.15Hz)
Total power of the 0-0.15 Hertz band, frequency-domain parameter Total power will be measured using the electrogastrogram \[EGG\]: EGG data will be recorded using 6 single use and adhesive electrodes placed on the skin of the abdomen.
Time frame: Up to 52 days from T1 (T3)
Slow-waves frequency (physiological outcome)
Slow-waves frequency per minute, frequency-domain parameter Slow-wave frequency will be measured using the electrogastrogram \[EGG\]: EGG data will be recorded using 6 single use and adhesive electrodes placed on the skin of the abdomen.
Time frame: Day 1 (T1)
Slow-waves frequency (physiological outcome)
Slow-waves frequency per minute, frequency-domain parameter Slow-wave frequency will be measured using the electrogastrogram \[EGG\]: EGG data will be recorded using 6 single use and adhesive electrodes placed on the skin of the abdomen.
Time frame: Up to 25 days from T1 (T2)
Slow-waves frequency (physiological outcome)
Slow-waves frequency per minute, frequency-domain parameter Slow-wave frequency will be measured using the electrogastrogram \[EGG\]: EGG data will be recorded using 6 single use and adhesive electrodes placed on the skin of the abdomen.
Time frame: Up to 52 days from T1 (T3)
Delta frequency (0-4Hz)
Delta frequency 0-4 Hertz band Delta frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Day 1 (T1)
Delta frequency (0-4Hz)
Delta frequency 0-4 Hertz band Delta frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Up to 25 days from T1 (T2)
Delta frequency (0-4Hz)
Delta frequency 0-4 Hertz band Delta frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Up to 52 days from T1 (T3)
Theta frequency (4-7Hz)
Theta frequency 4-7 Hertz band Theta frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Day 1 (T1)
Theta frequency (4-7Hz)
Theta frequency 4-7 Hertz band Theta frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Up to 25 days from T1 (T2)
Theta frequency (4-7Hz)
Theta frequency 4-7 Hertz band Theta frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Up to 52 days from T1 (T3)
Alpha frequency (8-12Hz)
Alpha frequency 8-12 Hertz band Alpha frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Day 1 (T1)
Alpha frequency (8-12Hz)
Alpha frequency 8-12 Hertz band Alpha frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Up to 25 days from T1 (T2)
Alpha frequency (8-12Hz)
Alpha frequency 8-12 Hertz band Alpha frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Up to 52 days from T1 (T3)
Beta frequency (13-30Hz)
Beta frequency 13-30 Hertz band Beta frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Day 1 (T1)
Beta frequency (13-30Hz)
Beta frequency 13-30 Hertz band Beta frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Up to 25 days from T1 (T2)
Beta frequency (13-30Hz)
Beta frequency 13-30 Hertz band Beta frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Up to 52 days from T1 (T3)
Gamma frequency (>30Hz)
Gamma frequency \>30 Hertz band Gamma frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Day 1 (T1)
Gamma frequency (>30Hz)
Gamma frequency \>30 Hertz band Gamma frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Up to 25 days from T1 (T2)
Gamma frequency (>30Hz)
Gamma frequency \>30 Hertz band Gamma frequency will be measured using the electroencephalogram \[EEG\]: EEG data will be recorded using a EEG headsets including 64 electrodes. The EEG is related to the brain activity generated by the neural functioning.
Time frame: Up to 52 days from T1 (T3)
Alexithymia score
Alexithymia score will be measured using the Bermond-Vorst Alexithymia Questionnaire B version (BVAQ-B; Vorst \& Bermond, 2001; French version Deborde et al., 2004). The subscale as considered as a trait scale including 20 items.
Time frame: Up to 16 days from T2
Neuroticism score
Neuroticism score will be measured using the Big Five Inventory-Neuroticism (BFI-N; John et al., 1991; French version Plaisant et al., 2005). The subscale as considered as a trait scale including 8 items.
Time frame: Up to 16 days from T1
Trait and state anxiety scores
The trai and state anxiety scores will be measured using the State-Trait Anxiety Inventory (STAI Y-AB) (Spielberger et al., 1983; French version Bruchon-Schweitzer \& Paulhan, 1990). The scale includes 40 items.
Time frame: Up to 8 days from T1
Style of coping
The style of coping will be measured using the Brief Cope (Carver, 1997; French version Muller \& Spitz, 2003). We will use it in its trait version. The subscale as considered as a trait scale including 28 items.
Time frame: Up to 16 days from T1
Positive affectivity score
Positive affectivity score will be measured using the Positive And Negative Affect Schedule (PANAS; Watson et al., 1988; French version Caci \& Bayle, 2007). To measure a global affective state, a score of positivity will be calculated by subtracting negative affect score from positive affect score. The subscale as considered as a state scale including 20 items.
Time frame: Day 1 (T1)
Positive affectivity score
Positive affectivity score will be measured using the Positive And Negative Affect Schedule (PANAS; Watson et al., 1988; French version Caci \& Bayle, 2007). To measure a global affective state, a score of positivity will be calculated by subtracting negative affect score from positive affect score. The subscale as considered as a state scale including 20 items.
Time frame: Up to 25 days from T1 (T2)
Positive affectivity score
Positive affectivity score will be measured using the Positive And Negative Affect Schedule (PANAS; Watson et al., 1988; French version Caci \& Bayle, 2007). To measure a global affective state, a score of positivity will be calculated by subtracting negative affect score from positive affect score. The subscale as considered as a state scale including 20 items.
Time frame: Up to 52 days from T1 (T3)
Depressive symptoms score
The depressive symptoms score will be measured using the Center for Epidemiologic Studies-Depression Scale (CES-D; Radloff, 1977; French version Führer \& Rouillon, 1989). The subscale as considered as a state scale including 20 items.
Time frame: Day 1 (T1)
Depressive symptoms score
The depressive symptoms score will be measured using the Center for Epidemiologic Studies-Depression Scale (CES-D; Radloff, 1977; French version Führer \& Rouillon, 1989). The subscale as considered as a state scale including 20 items.
Time frame: Up to 25 days from T1 (T2)
Depressive symptoms score
The depressive symptoms score will be measured using the Center for Epidemiologic Studies-Depression Scale (CES-D; Radloff, 1977; French version Führer \& Rouillon, 1989). The subscale as considered as a state scale including 20 items.
Time frame: Up to 52 days from T1 (T3)
Perceived-stress level
The perceived-stress level will be measured using the Perceived Stress Scale (PSS; Cohen et al., 1983; French version Bellighausen et al., 2009). The subscale as considered as a state scale including 10 items.
Time frame: Day 1 (T1)
Perceived-stress level
The perceived-stress level will be measured using the Perceived Stress Scale (PSS; Cohen et al., 1983; French version Bellighausen et al., 2009). The subscale as considered as a state scale including 10 items.
Time frame: Up to 25 days from T1 (T2)
Perceived-stress level
The perceived-stress level will be measured using the Perceived Stress Scale (PSS; Cohen et al., 1983; French version Bellighausen et al., 2009). The subscale as considered as a state scale including 10 items.
Time frame: Up to 52 days from T1 (T3)
Coping flexibility
The coping flexibility score will be measured using the Coping Flexibility Scale (CFS; Kato, 2012). The CFS measures the coping flexibility including 10 items. The subscale as considered as a state scale.
Time frame: Day 1 (T1)
Coping flexibility
The coping flexibility score will be measured using the Coping Flexibility Scale (CFS; Kato, 2012). The CFS measures the coping flexibility including 10 items. The subscale as considered as a state scale.
Time frame: Up to 25 days from T1 (T2)
Coping flexibility
The coping flexibility score will be measured using the Coping Flexibility Scale (CFS; Kato, 2012). The CFS measures the coping flexibility including 10 items. The subscale as considered as a state scale.
Time frame: Up to 52 days from T1 (T3)
Metacoping
The metacoping score will be measured using a visual analogue scale (VAS). The VAS was developed by ourselves to measure the perceived effectiveness of coping by asking: " how strategies used by yourself to cope with the situation were efficient? ". The participants will have to rate from 0 (no efficacy) to 10 (maximum of efficacy). The subscale as considered as a state scale.
Time frame: Day 1 (T1)
Metacoping
The metacoping score will be measured using a visual analogue scale (VAS). The VAS was developed by ourselves to measure the perceived effectiveness of coping by asking: " how strategies used by yourself to cope with the situation were efficient? ". The participants will have to rate from 0 (no efficacy) to 10 (maximum of efficacy). The subscale as considered as a state scale.
Time frame: Up to 25 days from T1 (T2)
Metacoping
The metacoping score will be measured using a visual analogue scale (VAS). The VAS was developed by ourselves to measure the perceived effectiveness of coping by asking: " how strategies used by yourself to cope with the situation were efficient? ". The participants will have to rate from 0 (no efficacy) to 10 (maximum of efficacy). The subscale as considered as a state scale.
Time frame: Up to 52 days from T1 (T3)
Social support score
The social support score will be measured using the Social Support Questionnaire short version (SSQ6; Sarason et al., 1987a; French version Bruchon-Schweitzer et al., 2003). The subscale as considered as a trait scale including 6 items.
Time frame: Up to 8 days from T1
Interceptive sensitivity score
The interceptive sensitivity score will be measured using the Multidimensional Assessment of Interoceptive Awareness second version (MAIA-2; Mehling et al., 2018). The subscale as considered as a trait scale including 37 items.
Time frame: Up to 8 days from T1
Life satisfaction score
The life satisfaction score will be measured using the Satisfaction With Life Scale (SWLS; Diener et al., 1985; French version Blais et al., 1989). The subscale as considered as a state scale including 5 items.
Time frame: Day 1 (T1)
Life satisfaction score
The life satisfaction score will be measured using the Satisfaction With Life Scale (SWLS; Diener et al., 1985; French version Blais et al., 1989). The subscale as considered as a state scale including 5 items.
Time frame: Up to 25 days from T1 (T2)
Life satisfaction score
The life satisfaction score will be measured using the Satisfaction With Life Scale (SWLS; Diener et al., 1985; French version Blais et al., 1989). The subscale as considered as a state scale including 5 items.
Time frame: Up to 52 days from T1 (T3)
Negative impact scores
The negative impact score will be measured using the Life Experiences Survey (LES; Sarason et al., 1978). The subscale as considered as a trait scale including 50 items. In this study a modified version of the LES will be used, whereby subjects documented the presence and perceived impact of adulthood life events that had occurred since 18 years of age to the time of completion of the survey. For the purposes of this study, 3 scores will be generated from this survey: the number of negatively perceived life events, the negative impact score determined by the sum of the impact scores of negatively perceived life events alone (higher scores indicate greater negative impact), and the total impact score determined by the sum of the impact scores of both negatively and positively perceived life events (higher scores indicate an overall more positive impact and lower scores indicate an overall more negative impact of all adulthood life events).
Time frame: Up to 16 days from T2
Frequency, severity and intensity scores
The frequency, severity and intensity scores will be measured using the Daily Hassles Scale (DHS; Kanner et al., 1981). The subscale as considered as a trait scale including 117 items.
Time frame: Up to 8 days from T2
Child Abuse scores
The child abuse scores will be measured using the Childhood Trauma Questionnaire-Short Form (CTQ; Bernstein et al., 2003). The subscale as considered as a trait scale including 28 items.
Time frame: Up to 16 days from T1
Acceptance score
The acceptance score will be measured using the Illness Cognition Questionnaire for chronic disease (ICQ-18; Evers et al., 2001). The subscale as considered as a state scale including 18 items.
Time frame: Day 1 (T1)
Acceptance score
The acceptance score will be measured using the Illness Cognition Questionnaire for chronic disease (ICQ-18; Evers et al., 2001). The subscale as considered as a state scale including 18 items.
Time frame: Up to 25 days from T1 (T2)
Acceptance score
The acceptance score will be measured using the Illness Cognition Questionnaire for chronic disease (ICQ-18; Evers et al., 2001). The subscale as considered as a state scale including 18 items.
Time frame: Up to 52 days from T1 (T3)