Intubation Conditions With Atracurium After Three Minutes

Assistance Publique - Hôpitaux de Paris100 enrolled

Overview

The purpose of this study is to evaluate intubation conditions with the use of atracurium after a fixed three-minute delay

The recommended dose of a non-depolarizing curare to facilitate tracheal intubation is twice the active dose 95 (the dose that reduces muscle force by 95%). At this dosage, curarization of the laryngeal adductors allowing relaxation and abduction (opening) of the vocal cords is considered certain. With atracurium, the dose for intubation is 0.5 mg.kg-1 and the time to full effect is approximately 3 minutes. With the use of newer hypnotics, there are no data evaluating the conditions for intubation after a fixed time of 3 minutes as with current anesthetic practices.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Obesity Female Patients Require General Anaesthesia With Intubation and Atracurium Curarization

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult female * Patient to undergo general anesthesia with intubation for scheduled gynecological surgery * Patient informed about the study and not opposed to it Exclusion Criteria: * Patients with severe and morbid obesity (BMI\>35kg/m2) * Pregnancy * Patients with difficult intubation * Allergy to atracurium and to any other drug used. * Patient under tutorship / curatorship * Not affiliated with social insurance * Patient with AME

Locations (1)

Service Anesthésie Réanimation Chirurgicale Hôpital Cochin

Paris, France

Outcomes

Primary Outcomes

Intubation condition

The intubating conditions were evaluated on the basis of the consensus conference on Good Clinical Research Practice in Pharmacodynamic Studies of Neuromuscular Blocking Agents. The score used include the following variables: (1) ease of laryngoscopy, (2) vocal cord position, and (3) reaction to the insertion of the endotracheal tube and the cuff inflation (eg, diaphragmatic movement due to patient cough). Each of these variables was rated as (1) excellent, (2) good, or (3) poor. Intubating conditions were scored as excellent if all variables were excellent; the score was good if at least 1 variable was good and the rest were excellent; the conditions were considered poor if any of the variables was rated poor. Evaluation of intubation conditions with the use of atracurium after a fixed three-minute delay

Time frame: 3 minutes after atracurium injection

Data from ClinicalTrials.gov

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