SEARCH SAPPHIRE Phase A: A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa

INDIVIDUAL LEVEL INCLUSION CRITERIA FOR COMPONENT INTERVENTIONS PrEP/PEP at Outpatient Clinics 1. Age ≥15 years 2. HIV-negative 3. Current or anticipated risk for HIV-infection PrEP/PEP at Antenatal Clinics 1. Age ≥15 years 2. HIV-negative 3. Current or anticipated risk for HIV-infection PrEP/PEP at Community Households 1. Age \> 15 years 2. HIV-negative 3. Current or anticipated risk for HIV-infection Mobility Dynamic Treatment Intervention 1. Age ≥15 years 2. HIV-positive 3. HIV RNA non-suppression (\>400 c/mL in the prior 12 months) or missed 2 visits in past 12 months or missed 2 visits in past 12 months or no VL measured in past 12 months 4. Travel outside the community ≥2 times in past 12 months 5. Enrolled or new to care in a study clinic Healthy Living Intervention for Heavy Alcohol Users 1. Age ≥18 years 2. HIV-positive 3. HIV RNA non-suppression (\>400 c/mL in the prior 12 months) or missed clinic visits (\>2 weeks or \<=90 days from last scheduled clinic visit) within past 6 months, or out of care without return to care (\>90 days from last scheduled clinic visit) within past 6 months 4. Heavy alcohol use per AUDIT-C tool (scores of ≥4 for men, and ≥3 for women) 5. Enrolled or new to care in a study clinic Hypertension Linkage Intervention 1. Age ≥25 years 2. Blood pressure ≥140/90 mmHg on three repeated measurements during community-based hypertension screening 3. Resident (by self-report) within catchment area of referral health center Community Hypertension Intervention 1. Age \>=40 2. Blood pressure ≥160/100 on average of 2nd and 3rd measurements at initial screening 3. Sustained blood pressure elevation to ≥140/90 at initial clinic enrollment visit INDIVIDUAL LEVEL EXCLUSION CRITERIA FOR COMPONENT INTERVENTIONS PrEP/PEP at Outpatient Clinics 1. \<15 years of age 2. Unable to provide consent or parental co-consent as per country guidelines 3. Participation in another Phase A RCT intervention component PrEP/PEP at Antenatal Clinics 1. \<15 years of age 2. unable to provide consent or parental co-consent as per country guidelines 3. Participation in another Phase A RCT intervention component PrEP/PEP at Community Households 1. \<15 years of age 2. unable to provide consent or parental co-consent as per country guidelines 3. Participation in another Phase A RCT intervention component Mobility Dynamic Treatment intervention 1. \<15 years of age 2. Participation in another Phase A RCT intervention component Healthy Living Intervention for Heavy Alcohol Users 1. \<18 years of age 2. Participation in another Phase A RCT intervention component 3. No access to mobile phone Hypertension Linkage Intervention 1. \<25 years of age 2. Plan to out-migrate from the catchment area of referral health center within 30 days of screening visit 3. Already engaged in hypertensive care (by self-report) 4. Blood pressure measure of ≥180/110 mmHg during screening symptoms of hypertensive emergency Community Hypertension Intervention 1. Pregnancy 2. Co-morbidities that preclude home monitoring