The study is being conducted to evaluate the efficacy and safety of HR021618 in the treatment of moderate to severe pain after abdominal surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
West China Hospital, Sichuan University
Chengdu, Sichuan, China
AUC48
Area under the pain intensity-time curve.
Time frame: 48 hours after recovery from anesthesia] Area under the pain intensity-time curve.
Total consumption of morphine over 0-48, 0-24, 24-48 hours
Total consumption of morphine after recovery from anesthesia.
Time frame: 48 hours after recovery from anesthesia
AUC3, AUC24, AUC15-21, AUC18-24, AUC24-28, AUC39-45, AUC42-48
Area under the pain intensity-time curve.
Time frame: 48 hours after recovery from anesthesia
Time of the first dose of rescue analgesia
Time of the first dose of rescue analgesia after recovery from anesthesia.
Time frame: 48 hours after recovery from anesthesia
Proportion of subjects receiving rescue analgesia
Proportion of subjects receiving rescue analgesia after recovery from anesthesia.
Time frame: 48 hours after recovery from anesthesia
Frequency of doses of rescue analgesia
Frequency of doses of rescue analgesia after recovery from anesthesia.
Time frame: 48 hours after recovery from anesthesia
Subjects' satisfaction rating
Subjects' satisfaction rating.
Time frame: 48 hours after recovery from anesthesia
Anesthesiologist satisfaction rating
Anesthesiologist satisfaction rating.
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Time frame: 48 hours after recovery from anesthesia