Latanoprost Plus NB-UVB Versus Each Alone in Non-segmental Vitiligo: Clinical and Laboratory Evaluation

Shaimaa Fawzy Abdel-rady Abdel-latif150 enrolled

Overview

The aim of the study is to evaluate the efficacy of different lines of therapies on the TWEAK serum level in patients with non-segmental vitiligo.

the study is to evaluate the efficacy of NB-UVB, latanoprost, and combination of them on the TWEAK serum level in patients with non-segmental vitiligo.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

150

Conditions

Non-segmental Vitiligo

Interventions

NB-UVBRADIATION

radiation

LatanoprostDRUG

eye drops

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with non-segmental vitiligo of any age and gender. Exclusion Criteria: * History of vitiligo treatment with topical, systemic or biological agents prior to the study for at least 3 weeks. * Pregnancy and lactation. * Infections * Patients with other autoimmune diseases. * Patients with chronic diseases: cardiac diseases, hepatic disorders, hematologic disease, chronic renal failure or malignancies.

Locations (1)

faculty of medicine, Aswan University

Aswān, Aswan Governorate, Egypt

Outcomes

Primary Outcomes

serum TWEAK in vitiligo

measurement of serum Tumor necrosis factor weak inducer of apoptosis (TWEAK)"pg/ml"; in vitiligo patients before and after treatment with NB-UVB, Latanoprost and their combination, all in comparison with healthy individuals, using ELISA (enzyme-linked immunosorbent assay)

Time frame: 3months

Secondary Outcomes

treatment of vitiligo

clinical evaluation: Assessment of the disease severity in non-segmental vitiligo will be performed by using vitiligo area severity index (VASI score) before and after treatment with NB-UVB, latanoprost application applied after microneedling, by using 1.5-2 mm needle length dermapen, of vitiligenous patches, or combination of both of them. Patients will be photographed at baseline and after 3 months of regular treatment by using high resolution digital camera conon EOS 1300D 18 megapixels (made in Taiwan), photography will be done in standard light and distance.

Time frame: 3 months

Data from ClinicalTrials.gov

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