Evaluation of the Effect of Narrowband UVB Versus Methotrexate on Serum TWEAK Level in Psoriasis

Phase 4UnknownNCT04811911

Aswan University Hospital30 enrolled

Overview

The aim of the study is to evaluate the effect of NB-UVB versus MTX on serum TWEAK level in psoriatic patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Psoriasis

Interventions

Narrowband ultraviolet BRADIATION

Patients will receive 8 sessions of NB-UVB per month for 3 successive months

MethotrexateDRUG

Patients will receive 25 mg/1ml of methotrexate vial per week for 3 successive months

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with moderate to severe plaque psoriasis of any age and gender. Exclusion Criteria: * History of psoriasis treatment with systemic and biological agents prior to the study for at least 3 months. * Pregnancy and lactation. * Infections * Patients with chronic diseases: hepatic disorders, hematologic disease, chronic renal failure or cancer

Locations (1)

Aswan University - Faculty of Medicine

Aswān, Aswan Governorate, Egypt

Outcomes

Primary Outcomes

Serum TWEAK in psoriasis

Measurement of tumor necrosis factor weak inducer of apoptosis (TWEAK) "pg/ml"; in psoriatic patients before and after treatment with NB-UVB versus MTX in comparison with healthy individuals, using ELISA (enzyme-linked immunosorbent assay).

Time frame: 3 months

Secondary Outcomes

Treatment of psoriasis

Clinical evaluation: Assessment of disease severity will be performed by using psoriasis area severity index (PASI score) before and after treatment with NB-UVB in comparison with MTX. Patients will be photographed at baseline and after 3 months of regular treatment by using high resolution digital camera canon EOS 1300D 18 megapixels (made in taiwan), photography will be done in standard light and distance.

Time frame: 3 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.