This crossover study is designed to compare the rates of gastric emptying between two diagnostic radioactive meals using the gold-standard egg-white sandwich meal and Abbott Vital®. Healthy participants will be recruited and randomly assigned into either groups of Abbott Vital® and gold-standard egg-white sandwich group. The measurements will be performed over a 4-hour period using a gamma camera, and estimated gastric emptying rates will be calculated using established algorithms.
The gold-standard egg-white sandwich is quite difficult and complicated for staffs to prepare because the food needs to be cooked first and it will take time to prepare. Besides, the egg-white sandwich is not suitable for those with allergies to egg and bread and also to vegetarian patients. This gold-standard meal is also not a common meal for Asian people so some of the people may not tolerate with the meal. The aim of this study is to determine whether Abbott Vital® is as reliable as the gold-standard egg-white sandwich by comparing the gastric meal retention of both meals.
Study Type
OBSERVATIONAL
Enrollment
30
1 mCi of Tc-99m sodium phytate is added into the egg-white sandwich
1 mCi of Tc-99m sodium phytate is added into the Abbott Vital®
Hospital Universiti Sains Malaysia
Kota Bharu, Malaysia
Change of gastric emptying rates
Percentage of gastric meal retention (GMR; %)
Time frame: 4 hours (0 hour, 1/2-hour, 1-hour, 2-hour, 3-hour, 4-hour)
Half-emptying time and slope
Time required by the stomach to empty 50% of the ingested meal (T1/2; minutes)
Time frame: T1/2
Symptoms and satiety/satiation
Intensity of perceived symptom and satiety/satiation based on Visual Analogue Scale (VAS)
Time frame: 4 hours (0 hour, 1/2-hour, 1-hour, 2-hour, 3-hour, 4-hour)
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