Use of Cyclosporine 0.1% Eye Drops as Prophylactic Treatment in cataract Surgery
To asses ocular discomfort symptoms and signs and inflammatory biomarkers after preoperative topical cyclosporine 0.1% eye drops therapy in high risk elder population after a specific insult such as cataract surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
101
one cyclosporine 0.1% eye drop twice a day for 30 preoperative days
one cationorm eye drop twice a day for 30 preoperative days
University Campus Bio Medico
Rome, Italy
Symptoms Assessment Questionnaire iN Dry Eye
SANDE (frequency and severity scores; 0-100)
Time frame: 4 months
National Eye Institute grading scale
NEI corneal staining ( n/15 score; 0-15)
Time frame: 4 months
Rate of tears' production
Schirmer test (mm/5min)
Time frame: 4 months
Tears Break Up Time
T-BUT (Seconds)
Time frame: 4 months
Biomarkers' expression in conjunctival epithelial cells
HLA DR (molecular expression)
Time frame: 4 months
Biomarkers' expression in conjunctival epithelial cells
ICAM-1 (molecular expression)
Time frame: 4 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.