The Effect of Minimal Flow Sevoflurane Anesthesia

Sisli Hamidiye Etfal Training and Research Hospital70 enrolled

Overview

Our aim is to investigate the effect of minimal flow anesthesia with sevoflurane on hemodynamics and arterial blood gas parameters in laparoscopic cholecystectomy operations.

Introduction: Low-flow anesthesia techniques have regained popularity in recent years with the development of low solubility volatile agents such as sevoflurane and desflurane, and modern anesthesia devices. Reducing the flow of fresh gas as much as possible will reduce the amount of volatile agent used, thus preventing air pollution, providing lower costs, and also preserving heat and moisture in the respiratory tract by using rebreathing systems. Laparoscopic surgery is superior to open surgical techniques due to its minimally invasive nature, less postoperative pain, less incidence of wound infections, shortening the hospitalization, and allowing patients to return to their normal lives sooner after the operation. Our aim is to investigate the effect of minimal flow anesthesia with sevoflurane on hemodynamics and arterial blood gas parameters in laparoscopic cholecystectomy operations. Material and Method: Seventy patients with ASA (American Society of Anesthesiologists) class I-II between the ages of 18-65 undergoing elective laparoscopic cholecystectomy were included in the study. After the patients were randomly selected by computer, they were divided into two equal groups as Group M (minimal flow anesthesia group) with fresh gas flow 0,5 L.min-1 and Group C (high flow anesthesia/ control group) with fresh gas flow 4 L.min-1. In both groups. Demographic data, duration of anesthesia, operation times, recovery times, hemodynamic parameters and arterial blood gas parameters of all patients were recorded. The patient data collected in both groups were compared statistically.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Anesthesia; Functional Anesthesia Awareness

Interventions

Sevoflurane inhalant productDRUG

The sevoflurane dose differed in both groups in relation to the fresh gas flow. Since the fresh gas flow is less in group M, the concentration of sevoflurane consumed by the patient at the end of the case will be less.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA (American Society of Anesthesiologists) class I-II * The operation time between 60-180 minutes Exclusion Criteria: * Severe cardiac disease * COPD (Chronic Obstructive Pulmonary Disease) * Severe liver and kidney disease, * Diabetes mellitus * Morbid obesity * Alcohol and/or drug addiction * Risk or history of malignant hyperthermia * Pregnancy and lactation * Emergency cases * Operation time less than 60 minutes and longer than 180 minutes

Locations (1)

Nebia Peker

Şişli, Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

CHANGE IN P/F

PaO2/FiO2 ratio is the ratio of arterial oxygen partial pressure (PaO2 in mmHg) to fractional inspired oxygen (FiO2 expressed as a fraction, not a percentage). P/F ratio is a widely used clinical indicator of hypoxaemia

Time frame: from the beginning to the end of anesthesia

CHANGE IN PaCO2

The partial pressure of carbon dioxide is the measure of carbon dioxide within arterial blood.

Time frame: from the beginning to the end of anesthesia

Secondary Outcomes

volatile agent consumption amount

the total amount of volatile agent (sevoflurane) consumed at the end of the surgery

Time frame: from the beginning to the end of anesthesia

Data from ClinicalTrials.gov

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