Intradiscal and Intra-articular Injection of Autologous Platelet-Rich-Plasma (PRP) in Patients With Lumbar Degenerative Disc Disease and Facet Joint Syndrome

Eligibility criteria will be distinctly applied in participants with lumbar DDD and FJS prior to treatment application. A. Participants with lumbar DDD Inclusion Criteria * Recurring low back pain persistent for more than 6 months demonstrating discogenic origin (i.e. localized at midline, exacerbated in seated position and alleviated in bed rest) * Failure of initially implemented conservative measures (medication regimen and/or physical therapy sessions or other injections) * Imaginary findings of Grade I-III DDD according to radiologic MRI-based classification proposed by Pfirrmann et al. (Pfirrmann et al., 2001) * Absence of exclusion criteria, as defined below. Exclusion Criteria * Presence of local or systemic infection signs (clinical and laboratory) * Concurrent known systemic inflammatory disease with musculoskeletal manifestations or other chronic inflammatory disease * Concurrent known hemorrhagic disorder or antithrombotic regimen * Presence of Grade IV-V DDD according to Pfirrmann classification (Pfirrmann et al., 2001) * Spondylolysis/Spondylolisthesis * Intervertebral Disc Herniation * Previous spinal surgery * Spinal Stenosis * Primary or Secondary spinal tumour * Spinal fracture in past 6 months * Diagnosed psychiatric disorder * Epidural steroid or other intradiscal injection or within past 30 days * Administration of NSAIDs, steroids or dietary supplements with anti-inflammatory properties within past 30 days. Β. Participants with lumbar FJS Inclusion Criteria * Recurring low back pain persistent for more than 6 months with no radiation to buttock or lower limb, presence of exacerbation in lateral bending, rotation and extension and paraspinal localization featuring reproduction with pressure. * Failure of conservative treatment measures (medication regimen and/or physical therapy sessions or other injections). * Radiologic findings of Grade I-II FJS according to CT-based classification proposed by Suri et al. (Suri et al., 2010) * Absence of exclusion criteria, as designated below. Exclusion Criteria * Clinical manifestations of radiculopathy * Presence of local or systemic infection signs (clinical and laboratory) * Concurrent known systemic inflammatory disease with musculoskeletal manifestations or other chronic inflammatory disease * Concurrent known hemorrhagic disorder or antithrombotic regimen. * Presence of Grade III-IV FJS according to proposed classification of Suri et al. (Suri et al., 2010) * Spondylolysis/Spondylolisthesis * Intervertebral Disc Herniation * Previous spinal surgery * Spinal Stenosis * Primary or Secondary spinal tumour * Spinal fracture in past 6 months * Diagnosed psychiatric disorder * Previous intra-articular steroid injection within past 30 days * Administration of NSAIDs, steroids or dietary supplements with anti-inflammatory properties within past 30 days.