Effects of Adapated Physical Activity Program on Kynurenin Metabolism During Refeeding in Anorexia Nervosa : APANOR Study

University Hospital, Rouen9 enrolled

Overview

Physical hyperactivity is often associated to anorexia nervosa (AN). Data suggest common central pathways between hyperactivity and anorexia. Maintaining adapted physical activity (APA) during refeeding in AN is controversial. Many studies suggest beneficits of APA in AN on body composition (increase fat free mass and better distribution of fat mass), mood regulation, bone metabolism. We recently reported benefits of maintaining physical activity during refeeding in a mice model of anorexia (activity-based anorexia model). These benefits involved the tryptophan-kynurenin pathway. Thus, we aim in the APANOR study to assess effects of APA during refeeding in AN on kynurenin metabolism.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Anorexia Nervosa

Interventions

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Female 2. Patient \> 18 years 3. Follow-up in the department of clinical Nutrition of Rouen 4. BMI ≥15,0 and \<18,5 kg/m² 5. Diagnosis of anorexia nervosa according to DSM-V classification Exclusion Criteria: 1. Physical activity contraindications : hemodynamic disorder, uncontrolled cardiovascular disease, intracranial hypertension 2. Patients with poor understanding of spoken or written French 3. Person deprived of their liberty by an administrative or judicial decision or person subject to a legal measure for the protection of adults 4. Person subject to a safeguard of justice, guardianship or curatorship. 5. Pregnant or breastfeeding woman

Outcomes

Primary Outcomes

To evaluate the effects of adapated physical activity (APA) program on kynurenin metabolism

Variation of plasmatic kynurenin acid between V1 and V2 in patients undergoing APA during refeeding versus other patients (control group without APA)

Time frame: 3 months

Secondary Outcomes

To evaluate the effects of adapated physical activity program on anthropometric data.

Anthropometric data

Time frame: 3 months

To evaluate the involving of gut microbiota composition and diversity

gut microbiota analyses

Time frame: 3 months

To evaluate the effects of adapated physical activity program on quality of life

Self-administered questionnaires assessing the quality of life

Time frame: 3 months

To evaluate the involving of auto-antibodies against neuropeptides involved in food intake regulation

Dosage of auto-antibodies against neuropeptides involved in food intake regulation using ELISA method (enzyme-linked immunosorbent assay)

Time frame: 3 months

To evaluate the effects of adapated physical activity program on Body composition (fat mass, fat free mass)

Mesaurement of fat and free mass

Time frame: 3 months

Effects of Adapated Physical Activity Program on Kynurenin Metabolism During Refeeding in Anorexia Nervosa : APANOR Study

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes