The study evaluates the acute effects of Helichrysum italicum on resting energy expenditure and substrate oxidation in humans. The resting energy expenditure and substrate oxidation will be measured by indirect calorimetry at baseline and after ingestion of either Helichrysum italicum infusion or hot water.
Bioactive compounds found in medicinal plants and plant extracts, such as polyphenols, represent the oldest and most widely used form of alternative or complementary treatments for the prevention and management of obesity. Their consumption is currently increasing in the population due to the high cost, potential adverse effects and limited benefits of currently available pharmaceutical drugs. Helichrysum italicum is a mediterranean plant with promising nutraceutical activities. The plant is known as a rich source of biologically active compounds such as polyphenolic antioxidants, which are recognized in the prevention of various non-communicable chronic diseases. However, most of its traditionally claimed uses have not yet been scientifically proven. The proposed study will investigate the acute effect of Helichrysum italicum infusion on resting energy expenditure, substrate oxidation, respiratory quotient and blood pressure in a pilot study of 11 male adults. It will be designed as a crossover study. Half of the participants will consume the Helichrysum italicum infusion and the other half will consume hot water. After seven days of washout period the participants will consume the alternate beverage.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
11
Active beverage or control beverage consumption after overnight fasting and calorimetry measurement on a single subject. After seven days washout period follows the consumption of the alternate beverage and measurements.
Active beverage or control beverage consumption after overnight fasting and calorimetry measurement on a single subject. After seven days washout period follows the consumption of the alternate beverage and measurements.
University of Primorska, Faculty of Health Sciences
Izola, Slovenia
Change in resting energy expenditure
Resting energy expenditure will be determined with indirect calorimetry.
Time frame: Change from baseline to 30 minutes and 120 minutes.
Changes in fat oxidation
Substrate oxidation will be determined with indirect calorimetry.
Time frame: Change from baseline to 30 minutes and 120 minutes.
Respiratory quotient
Respiratory quotient will be determined with indirect calorimetry.
Time frame: Change from baseline to 30 minutes and 120 minutes.
Blood pressure
Systolic and diastolic blood pressures will be determined with blood pressure device (Omron M3)
Time frame: Change from baseline to 30 minutes and 120 minutes.
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