Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome

Inclusion Criteria: * Subject is a male or a female aged ≥ 18 years * Have given their written consent to participate in the study * Use of artificial tears (AT), autologous serum or specific dry eye medications during the last 6 months prior to the selection * Willing to not use AT or autologous serum for the study duration * VAS scale for Dry Eye Symptom Score ≥ 40 * Total CFS ≥ 5 * Schirmer's test with anesthesia \< 10 mm/5min * Patients with Sjögren Syndrome Exclusion Criteria: * Any concomitant treatment or prior ocular procedure or surgery, or alteration of the dose of systemic medications at the time of entry into the study * Use of contact lenses during the study * Significant Eye diseases according to investigator's opinion