Effect of Amino Acid Addition to a Drink on the Appearance of Ingested Water in Body Fluids1

N/ACompletedNCT04819334

Loughborough University15 enrolled

Overview

To determine the effects of a moderate amount of amino acids on the rate of water absorption and availability as a precursor fluid for sweat. Young and healthy (male or female) volunteers will take part in three experimental trials. In each trial, volunteers will be given one of two commercially available sports drinks or a commercially available sport drink with added amino acids in a double-blinded, randomised, crossover design. Each drink will be a single 600 mL bolus. All beverages will be labelled with deuterium (D2O). Trials will be compared for temporal accumulation of deuterium in plasma over the course of 60 minutes. Whole blood measurements of haemoglobin and haematocrit will also be made and plasma volume changes calculated. It is hypothesised that the amino acid trial will increase the rate of fluid absorption.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Rate of Water Appearance/Delivery in the Blood Water Balance

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Generally fit and healthy (determined by health screen questionnaire) * Recreationally active (minimum 3 hours of physical activity per week including walking) Exclusion Criteria: * Any cardiovascular, gastrointestinal, renal or acute/chronic health conditions that may influence the outcomes * Smoking (including vaping) * BMI of greater than 30 (combined with a body fat percentage greater than 20%) or BMI lower than 17.5