Platelet-Rich Plasma and Hip Osteoarthritis

N/ACompletedNCT04820231

Sisli Hamidiye Etfal Training and Research Hospital35 enrolled

Overview

To evaluate the effect of platelet-rich plasma (PRP) injection on pain, function and quality of life in patients with hip osteoarthritis.

After being informed about the study and potential risk, all patients giving written informed consent will undergo study entry. Each patient received three times intra-articuler injections of PRP under ultrasound guidance, and they were administered once a week. Baseline: Visual Analog Scale (VAS) including movement, rest and night, the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and SF-36 assessment 1st month: VAS, WOMAC and SF-36 assessment 3rd month: VAS, WOMAC and SF-36 assessment 6th month: VAS, WOMAC and SF-36 assessment

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hip Osteoarthritis

Interventions

intra-articular PRP injectionOTHER

Eligibility

Sex: ALLMin age: 50 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Hip pain VAS \> 4 * Grade 1 and 2 osteoarthritis according to the Kellgren-Lawrence classification * No pathologies in the laboratory and coagulation parameters Exclusion Criteria: * Rheumatological disease with hip involvement * Systemic active infection * Severe cardiovascular disease * Malignancy * NSAID usage in the last week * History of hip joint surgery * History of traumatic hip injury * Hgb values \< 11 gr/dl * Platelets values \< 150.000 / µl * History of bleeding disorder

Locations (1)

Şişli Hamidiye Etfal Training and Research Hospital

Istanbul, Şişli, Turkey (Türkiye)

Outcomes

Primary Outcomes

Change from baseline Visual Analog Scale (VAS) score at 1-month, 3-month and 6-month

The VAS is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between 'no pain' and 'worst pain'.

Time frame: Baseline, 1st month, 3rd month, 6th month

Change from baseline Western Ontario and McMaster University Osteoarthritis Index (WOMAC) score at 1-month, 3-month and 6-month

The scores for each subscale are summed up, with a possible score range of 0-20 for Pain, 0-8 for Stiffness, and 0-68 for Physical Function. Usually a sum of the scores for all three subscales gives a total WOMAC score, however there are other methods that have been used to combine scores. Higher scores: worse pain, stiffness, and functional limitations.

Time frame: Baseline, 1st month, 3rd month, 6th month

Change from baseline SF-36 score at 1-month, 3-month and 6-month

The SF-36 is a 36-item self-report measure of health-related quality of life. It has eight subscales measuring different domains of health-related quality of life: physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional, and mental health . Two component scores are derived from the eight subscales: a physical health component score and a mental health component score. High scores: good quality of life

Time frame: Baseline, 1st month, 3rd month, 6th month

Data from ClinicalTrials.gov

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