Infusion of Autologous T Regulatory Cells (T Reg) at the Time of Transplantation of Allogenic Islets of Langerhans

Inclusion Criteria: * Patient must be registered on the waiting list within The Nordic Network for Clinical Islet Transplantation * Type 1 diabetes with diagnosed \<40years of age and with\>5 years of exogenous insulin use * C peptide \< 0.1 nmol/L at MMTT if no previous islet transplant * Adequate previous treatment by an experienced diabetologist * Patient must understand and be able to sign an informed consent Exclusion Criteria: * Patient with a previous transplant other than islets * Patient with an BMI\>30 * Patient with an need of more than 1U/kg of insulin per 24h * Repeated abnormal liver function tests * non stable retinopathy * known abnormalities in coagulation * known malignancies * non stable heart conditions * active infections * serological proof of hepatitis B or C or HIV * signs of portal hypertension * patients that are pregnant, breast feeding or aim to become pregnant during the study period * patients with a PRA \> 20%, positive cross match or known DSA * patients with conditions that the investigator would consider unsafe to combine with islet transplantation