Prematurity birth lead to an early breaking link with the in utero environment. A special attention is brought in the neonatal intensive care units to reduce noise and lighting surrounding aiming to protect the newborn. During the uterine life fetus benefits previously of several auditory stimulations by the maternal voice, the mother's heartbeat. After birth the auditory environment is dramatically modified. Aim of this study is to submit to the newborn an audio recording of his mother's heart beat to analyze the comfort, stress and autonomic response. Heart rate variability (HRV) analysis is a non-invasive tool able to consider autonomic nervous system activity. Previous studies have shown that pleasant feelings are associated with an increase of high frequencies variations index (HFnu index) reflecting a prevalence of parasympathetic activity in the sympathetic-parasympathetic balance. This one can be simply assess by a monitor named NIPΣ and can provide a comfort index by quantifying the parasympathetic tone.
The study will imply 40 preterm and term newborns hospitalized in neonatal intensive care units of the University Hospital of Saint-Etienne (France).
Study Type
OBSERVATIONAL
Enrollment
30
Record of maternal heart sounds (heartbeats) with an electronic stethoscope during 10 minutes.
Each newborn included will have 20 minutes of an acoustic listening of their mother heartbeats previously recorded.
Recording of the newborn's heart rate: one hour before the acoustic listening, during the acoustic listening and one hour after the acoustic listening . The variations of the autonomic nervous system will be analyzed. An coupled Heart rate variability recording (ECG signal obtained from a Philips® IntelliVue MX700 monitor) and NIPΣ index of comfort (MDMS® NIPΣ monitor) will be used.
Chu Saint-Etienne
Saint-Etienne, France
NIPΣ index
Analyze variations of the activity of the autonomic nervous system (R-R cardiac interval) NIPΣ index (from 0 to 100) obtained from an MDoloris® monitor. The base line is measured one hour before
Time frame: During the acoustic listening
HFnu (normalized high frequency) index.
Measured by analyze of record's of newborn heart rate. The base line is measured one hour before
Time frame: During the acoustic listening
HFnu (normalized high frequency) index.
Measured by analyze of record's of newborn heart rate.
Time frame: One hour after the acoustic listening
Standard deviation of all NN intervals (SDNN)
Measured by analyze of record's of newborn heart rate
Time frame: During the acoustic listening
Standard deviation of all NN intervals (SDNN)
Measured by analyze of record's of newborn heart rate
Time frame: One hour after the acoustic listening
Proportion of NN50 divided by the total number of NN intervals (pNN50)
Measured by analyze of record's of newborn heart rate
Time frame: During the acoustic listening
Proportion of NN50 divided by the total number of NN intervals (pNN50)
Measured by analyze of record's of newborn heart rate
Time frame: One hour after the acoustic listening
Root mean square of the successive differences (RMSSD).of RR interval
Measured by analyze of record's of newborn heart rate.
Time frame: One hour after the acoustic listening
Root mean square of the successive differences (RMSSD).of RR interval
Measured by analyze of record's of newborn heart rate.
Time frame: During the acoustic listening
Total power spectrum (Ptot)
Measured by analyze of record's of newborn heart rate.
Time frame: During the acoustic listening
Total power spectrum (Ptot)
Measured by analyze of record's of newborn heart rate.
Time frame: One hour after the acoustic listening
Low Frequency (LF)
Measured by analyze of record's of newborn heart rate.
Time frame: During the acoustic listening
Low Frequency (LF)
Measured by analyze of record's of newborn heart rate.
Time frame: One hour the acoustic listening
High Frequency (HF)
Measured by analyze of record's of newborn heart rate.
Time frame: During the acoustic listening
High Frequency (HF)
Measured by analyze of record's of newborn heart rate.
Time frame: One hour after the acoustic listening
Very Low Frequency (VLF)
Measured by analyze of record's of newborn heart rate.
Time frame: During the acoustic listening
Very Low Frequency (VLF)
Measured by analyze of record's of newborn heart rate.
Time frame: One hour after the acoustic listening
Ratio Low Frequency (LF) / High Frequency (HF)
Measured by analyze of record's of newborn heart rate.
Time frame: During the acoustic listening
Ratio Low Frequency (LF) / High Frequency (HF)
Measured by analyze of record's of newborn heart rate.
Time frame: One hour after the acoustic listening
Heart rate (bpm)
Measured by analyze of record's of newborn heart rate.
Time frame: During the acoustic listening
Oxygen saturation (%)
Measured by analyze of record's of newborn heart rate.
Time frame: During the acoustic listening
NIPΣ index
Analyze variations of the activity of the autonomic nervous system (R-R cardiac interval) NIPΣ index (from 0 to 100) obtained from an MDoloris® monitor.
Time frame: One hour after the acoustic listening
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