Patients going through an in vitro fertilization cycle will be asked to participate . Patients will be asked for their COVID-19 exposure : post confirmed disease/post vaccine/not exposed to disease or vaccine . Patients will provide the fluids which are not required , once fertilization process is completed. Patients will also provide 5ml blood sample by the day of procedure. Anti COVID-19 immunoglobulin G type antibodies will be measured in all samples . Data regarding age, date of infection/vaccine will be collected . Progesterone and Estrogen will be measured in female patients' samples and Perlecan level will be measured in follicular fluid.
Patients going through an in vitro fertilization cycle will be asked to participate . Patients will be asked for their COVID-19 exposure : post confirmed disease/post vaccine/not exposed to disease or vaccine . Patients will provide the fluids which are not required in the day of egg retrieval : the follicular fluid remaining after isolation of the egg and spermatic fluid only, if not utilized for fertilization. The fluids will be collected once fertilization process is completed. Patients will also provide 5ml blood sample by the day of procedure. Anti COVID-19 immunoglobulin G type antibodies will be measured in all samples . Data regarding age, date of infection/vaccine will be collected as well as indication for treatment, Estradiol level before the egg retrieval, number of eggs collected and the triggering ovulation modality . Progesterone and Estrogen will be measured in female patients' samples (follicular fluid and serum). Perlecan level will be measured in follicular fluid.
Study Type
OBSERVATIONAL
Enrollment
50
Detection of antibodies to SARS Cov 19 post infection or vaccination , measurements of female hormones in folicular fluid as compared to serum and Perlecan as a follicular quality marker
Meir Medical Center
Kfar Saba, Israel
RECRUITINGFollicular - Serum Anti COVID-19 antibody (Immunoglobulin G) ratio
The relationship between antibodies to COVID-19 in serum to follicular fluid in female patients going through an egg retrieval
Time frame: Through study completion, expected 2 months
Spermatic fluid- Serum Anti COVID-19 antibody (Immunoglobulin G) ratio
The relationship between antibodies to COVID-19 in serum to spermatic fluid in male patients going through in vitro fertilization treatment
Time frame: Through study completion, expected 2 months
Follicular fluid Estradiol level (pmol/L)
Quality assessment of follicular fluid as measured by Estradiol level
Time frame: Through study completion, expected 2 months
Follicular fluid Progesterone level (nmol/L)
Quality assessment of follicular fluid as measured by Progesterone level
Time frame: Through study completion, expected 2 months
Follicular fluid Perlecan level (nmol/L)
Quality assessment of follicular fluid as measured by Perlecan level
Time frame: Through study completion, expected 2 months
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