Determining the Presence of RAP in Orthognathic Patients and Its Effect on Root Resorption by Biomarkers

Bezmialem Vakif University13 enrolled

Overview

A prospective clinical trial to what extent inflammatory biomarkers are affected by the medication after orthognathic surgery in early surgical cases and whether these biomarkers affects the amount of maxillary or mandibular incisor root resorption.

To conduct a prospective clinical trial to what extent inflammatory biomarkers such as OPG, RANKL, IL-1, IL-6, and CRP are affected by the medication after orthognathic surgery in early surgical cases and whether these biomarkers affects the amount of maxillary or mandibular incisor root resorption.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Class III Malocclusion Root Resorption

Interventions

Orthognathic SurgeryPROCEDURE

The duration for presurgical orthodontic treatment was; 7,7 ± 1,7 months.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria 1. Have skeletal Cl III malocclusion 2. Wisdom teeth are absent or extracted at least 6 months before the surgery 3. Need of orthognathic surgery through Le Fort I osteotomy of the maxilla and bilateral sagittal split osteotomies (BSSO) of the mandible. 4. Undergo fixed orthodontic treatment before and after the orthognathic surgery 5. Have available orthopantomograms with adequate quality 6. Have healthy periodontal tissue without inflammation or bleeding before and after the surgery. 7. Maintain the same medication protocol during and after the surgery. Exclusion Criteria: 1. ongoing use of regular medication 2. smoking 3. known penicillin allergy, 4. any immune disorder, 5. musculoskeletal diseases, 6. syndromes, 7. cleft lip-palate, 8. systemic diseases affecting root resorption, 9. periodontal and gingival disorders, 10. missing teeth among upper or lower incisors, 11. poor oral hygiene.

Locations (1)

Banu Kilic

Istanbul, Fatih, Turkey (Türkiye)

Outcomes

Primary Outcomes

Assessing Change Between Three Time Points of Biomarkers to Determine Effectiveness of Regional Acceleratory Phenomenon

IL- 6 RANKL

Time frame: To see the change at biomarker levels GCF samples were collected at the time points designated as T0, T1, and T2 which correspond to the day of the surgery before anesthesia, 1 week after the surgery, and 4 weeks after the surgery

Assessing Change Between Two Time Points to Determine Root Resorption

Morphologic changes in root apex

Time frame: To see the change of root length all radiographs were taken digitally at t0 (at the beginning of orthodontic preparation), t1 (just before the orthognathic surgery), and t2 ( an average of 1,5 years postop) with an X-ray unit

Data from ClinicalTrials.gov

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