Sequential comparative prospective interventional study evaluating the impact of the use of an optimization device of the decision of cancer treatment on aggressiveness of end of life care. Comparison between a first period, period (A), of care as usual and a second period, period (B), of systematic and iterative use of a device for optimizing the decision to continue an anti-cancer treatment.
We propose to study the optimization of this decision process in an advanced Non-Small-Cell Lung Carcinoma (NSCLC) population, with a Performance Status (PS) ≥ 2 (median survival of approximately 3 months) piloting iteratively (before each decision to continue treatment) a process consisting of an evaluation framework (30 items to be answered by the oncologist with the patient), consolidating: 1. clinical parameters; 2. doctors' expectations regarding the continuation of anticancer treatment; 3. patient expectations and preferences; 4. the possibility of referring the patient to a supportive care specialist and strengthening home care. The process triggers a dialogue between the patient and the oncologist, based on facts and seeks objectivity, ultimately allowing a shared decision. In this prospective comparative study, the rate of systemic oncological treatment during the last month of life will be measured consecutively, over a period of usual management, followed by a period of systematic application of a process of optimization of the medical decision.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
364
Patients receiving systemic anticancer treatment in their last days of life
Impact of the use of an optimization device of the decision of cancer treatment on aggressiveness of end of life care
CH Abbeville
Abbeville, France
CH du Pays d'Aix
Aix-en-Provence, France
Percentage of patients receiving systemic anticancer treatment in their last days of life
Comparison of the percentage of patients receiving systemic anticancer treatment in their last 30 days of life during each period
Time frame: 24 months
Percentage of chemotherapy
Percentage of chemotherapy (IV, oral) administered in the last 60, 30 and 14 days of life,
Time frame: 24 months
Number of emergency room visits
Percentage of patients visiting emergency room visits more than once and of unplanned hospitalizations and intensive care admission in the last month of life.
Time frame: 24 months
Percentage of initiation of a new line of chemotherapy
Percentage of initiation of a new line of chemotherapy (IV, oral) in the last month of life
Time frame: 24 months
Percentage of immunotherapy and of Tyrosine kinase inhibitor
Percentage of immunotherapy and of Tyrosine kinase inhibitor in the last 60, 30 and 14 days of life.
Time frame: 24 months
Percentage of initiation of Tyrosine kinase inhibitor or immunotherapy
Percentage of initiation of Tyrosine kinase inhibitor or immunotherapy in the last month of life.
Time frame: 24 months
Use of supportive care
Frequency and precocity of use of supportive care.
Time frame: 24 months
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CHU Amiens - Hôpital Sud
Amiens, France
CHU Angers
Angers, France
CHR Metz-Thionville - Hôpital de Mercy
Ars-Laquenexy, France
CH Henri Duffaut Avignon
Avignon, France
Institut Sainte-Catherine
Avignon, France
AP-HP Ambroise Paré
Boulogne-Billancourt, France
CHI de Compiègne-Noyon
Compiègne, France
CHU Sud Francilien
Corbeil-Essonnes, France
...and 15 more locations
Overall survival (OS)
Overall survival (OS) defined as the time from the date of consent to the date of death due to any cause.
Time frame: 24 months
Quality of life using QLQ-C15-PAL EORTC (European Organization for Research and Treatment of Cancer) and anxiety with HAD (Hospital Anxiety and Depression) questionnaire
The quality of Life in palliative cancer care patients will be collected with QLQ-C15-PAL EORTC scale and anxiety will be mesured with HAD scale.
Time frame: 24 months