The study aim is to evaluate whether DPP4-inhibitor could reduce coronary atherosclerosis assessed by CT scan in patients receiving insulin for diabetes mellitus. In this retrospective study, changes in obstructive coronary artery disease prevalence and coronary calcium burden between two coronary CT scans will be compared in patients with and without receiving DPP4-inhibitor.
This is a retrospective study using medical records in two hospitals affiliated to the Catholic University of Korea. Patients with diabetes mellitus who received insulin are retrospectively enrolled. Among those, only patients who underwent coronary CT scan for more than two times will be included. Included patients will be classified into DPP4-inhibitor group and no DPP4-inhibitor group according to the prescribed medication. The changes in obstructive coronary artery disease prevalence and coronary calcium score per one year will be compared between the two groups.
Study Type
OBSERVATIONAL
Enrollment
4,007
Prescription of DPP4-inhibitor during the period between the two coronary CT scan
No prescription of DPP4-inhibitor during the period between the two coronary CT scan
Bucheon St. Mary's Hospital
Bucheon-si, South Korea
Prevalence of obstructive coronary disease
Change in the prevalence of obstructive coronary disease, defined as \>50 percent stenosis in coronary CT scan
Time frame: one year
Change in coronary calcium score
Change in coronary calcium score, measured by two coronary CT scan per one year. Agatston score has minumum value of 0 and no maximum vavlue. Higher agatston score indicated severe calcification and worse outcome
Time frame: one year
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