Study on the Risks of Symptomatic Dengue on Pregnancy

Centre Hospitalier Universitaire de la Réunion336 enrolled

Overview

Dengue fever is the most common arbovirus worldwide (390 million people infected per year) and is a global public health problem. This public health problem is also becoming European due to its rapid expansion over the past decade with an increase in cases of 400% and the appearance of the first indigenous cases of dengue in Europe. Studies on the consequences of dengue fever on pregnancy find contradictory results. In fact, most of these studies are observational studies describing the risk of dengue fever for pregnancy, without comparison with a control group or comparing the different pregnancy morbidities to those found during pregnancy in the general population. Other research is retrospective case-control studies with major biases in the definitions of obstetric complications, which makes the results questionable. The study therefore proposes to carry out a prospective case-control study with rigorous matching criteria, strict definitions of cases, controls and obstetric complications.

Study Type

OBSERVATIONAL

Enrollment

336

Conditions

Dengue Pregnancy

Interventions

data collection

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for the case : * Pregnant patients * Major * Affiliated with social security * Symptomatic or pauci-symptomatic dengue * Biological confirmation of dengue fever Inclusion Criteria for the control : * Pregnant patients * Major * Affiliated with social security * Asymptomatic Exclusion Criteria for the 2 group : * Multiple pregnancy * Patient's refusal * Protected persons: person deprived of liberty by judicial or administrative decision, minor, and person subject to a legal protection measure: guardianship or curators)

Outcomes

Primary Outcomes

Evaluate the difference in the proportion of intrauterine growth retardation (IUGR) between the Case group and the Control group

Birth weight \<3rd percentile according to Sentinel Network Perinatal Database : AUDIPOG

Time frame: at childbirth

Secondary Outcomes

Evaluate the difference in the proportion of prematurity between the case group and the control group

Prematurity: birth between 22 and 37 weeks of amenorrhea

Time frame: at childbirth

Evaluate the difference in the proportion of late miscarriage between the case group and the control group

late miscarriage: Birth between 14 and 22 weeks of amenorrhea

Time frame: at childbirth

Evaluate the difference in the proportion of fetal death in utero between the case group and the control group

fetal death in utero : Negative cardiac activity in utero between 14 weeks and before childbirth

Time frame: at childbirth

Evaluate the difference in the proportion of preeclampsia between the case group and the control group

preeclampsia: Arterial hypertension\> 140 and / or 90 mmHg and proteinuria / 24h\> 0.3g / 24h

Time frame: at childbirth

Evaluate the difference in the proportion of bleeding from delivery between the case group and the control group between the case group and the control group

bleeding from delivery: Blood loss\> 500 mL in immediate postpartum up to 2 hours postpartum

Time frame: at childbirth

Evaluate the difference in the proportion of small weight for gestational age between the case group and the control group between the case group and the control group

Birth weight \<10th percentile according to Sentinel Network Perinatal Database : AUDIPOG

Time frame: at childbirth

Study on the Risks of Symptomatic Dengue on Pregnancy

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts