Atopic dermatitis is a common inflammatory skin disease, resulting from genetical, immunological and environmental factors. Head and neck are among the most frequent involved areas, almost 50% in adult patients according to most publications. Palpebral involvement is also common and a source of major quality of life impairment for patients. However, the real frequency of this palpebral involvement is unknown, only estimated about 20% in few studies. The treatment of this location remains difficult, regarding to the thickness of palpebral skin and proximity of the eye. To our knowledge, no prospective studies about allergological skin tests (such as patch-tests) in atopic patients with palpebral involvement had been conducted. Finally, atopic dermatitis is frequently associated with ophthalmological diseases such as conjunctivitis, keratoconus or cataract, which belong to the minor criteria of Hanifin and Rakja classification. A better knowledge of the atopic dermatitis palpebral involvement and the associated factors seems to be needed to improve the treatment and the quality of life of patients
Study Type
OBSERVATIONAL
Enrollment
550
with clinical examination, score filling such as SCORAD and DLQI * Standard Allergy consultation, with clinical examination, research of atopic or allergic personal and familial history * Allergy skin testing: patch tests with the Standard European Battery and with some products bring by the patient if necessary, skin prick tests with aero allergens. Two reading of the patch tests will be performed, at H48 and H72. * ophthalmologic consultation with slit lamp examination and OSDI (self questionnaire)
Hop Claude Huriez Chu Lille
Lille, France
RECRUITINGHopital Charles Nicolle Chu Rouen
Rouen, France
RECRUITINGRatio of palpebral involvement in adult atopic dermatitis patients, regardless the severity of the disease
Time frame: At Baseline, the initial consultation of dermatology
Clinical description of the palpebral involvement : acute eczema or chronic eczema
Time frame: At Baseline, the initial consultation of dermatology
Potential factors associated with palpebral involvement of the atopic dermatitis (socio-demographics factors, clinical factors, comorbidities, treatment, severity …)
Time frame: At Baseline, (the initial consultation of dermatology ) and at 3 months during the consultation of allergology
Rate of relevant contact sensitization according to the skin testing and the clinical manifestations
Time frame: At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours
Description of the sensitization profile
Time frame: At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours
Association between allergic sensitization and severity of the atopic dermatitis
Time frame: At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours
Rate of ophthalmologic comorbidities in association with palpebral involvement of the atopic dermatitis
Time frame: At 3 months during the time of the ophthalmologic consultation
Clinical description of the ophthalmologic involvement and OSDI scoring
Time frame: At 3 months during the time of the ophthalmologic consultation
Association between allergic sensitization and ophthalmologic involvement
Time frame: At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours
Association between ophthalmologic involvement and severity of the atopic dermatitis
Time frame: At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours
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