Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics

University of Arkansas44 enrolled

Overview

A randomized study to demonstrate how animal-based protein-rich food sources can be used by older adults to increase protein intake within pre-existing dietary patterns.

Current dietary patterns of older Americans will be augmented by readily available quality protein sources. Investigators will observe the effects of recommended and common protein intakes on the maintenance of whole-body protein balance and potential for muscle protein anabolism. 3 groups of 10 older subjects will be studied during daily protein intakes. Study duration per subject will be about 2 weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Sarcopenia

Interventions

0.8 g/kg/day protein intake

Habitual protein intakeOTHER

1.0 g/kg/day protein intake

Optimal Protein IntakeOTHER

1.5 g/kg/day protein intake

Eligibility

Sex: ALLMin age: 50 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI ≤ 35 kg/m2 * Capable of providing informed consent * COVID-19 negative and/or asymptomatic Exclusion Criteria: * Subject who does not/will not eat animal protein sources. * Body mass index \> 35. * History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment. * Use of insulin to control blood sugar level. * Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy. * Currently using prescription blood thinning medications. * Unable or unwilling to suspend aspirin use for 7 days prior to Visit 3. * Unwilling to avoid using protein or amino-acid supplements during participation.

Locations (1)

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Outcomes

Primary Outcomes

Whole Body Protein Turnover

Isotope Tracer

Time frame: 24 hour

Data from ClinicalTrials.gov

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