The aim of this study is to demonstrate a significant reduction of at least 25% in opioid consumption at 48 hours of management of severe trauma, while demonstrating non-inferiority in terms of analgesia, in a group of patients receiving a continuous infusion of low dose ketamine compared to a placebo group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
140
Administration of ketamin during the 48h after trauma
Service Anesthésie Réanimation - Hôpital nord
Marseille, France
Total dose of sufentanil
All doses of sufentanil and opiods administration
Time frame: 48 hours
Total amount of opiods
Time frame: 5 days
Pain assessment
Time frame: 5 days
Delirium
Scale CAM-ICU (confusion assesment method)
Time frame: 5 days
Global Quality of life
SF-36 score
Time frame: 3 months
Chronical pain
SF-MPQ-2
Time frame: 3 months
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