Evaluation and Importance of the PD-1/PD-L1 and the IL-10/IL-10R Axis in Malignant and Benign Pleural Effusions - a Pilot Study

University of Vienna80 enrolled

Overview

The aim of this study is to evaluate the concentrations of interleukin-2, interleukin-10, interferon-gamma, PD1+ lymphocytes, and the interleukin-10 receptor expression in malignant and benign effusions.

In this prospective trial, 80 patients with pleural effusions and indication for thoracocentesis, drainage, indwelling pleural catheter (IPC) management and/or video-assisted thoracoscopic surgery are enrolled. The pleural effusion will be examined for different cytokines, cytokine-receptors, PD1-lymphocytes and CD4+/CD25+/Foxp3+ regulatory T cell.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pleural Effusion

Interventions

Pleural effusion will be examined for various cytokines and PD1-lymphocytes.DIAGNOSTIC_TEST

Examination of pleural effusion

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \>18 years * radiologically confirmed pleural effusion with an indication for puncture, pleural drain insertion, or video-assisted thoracoscopy for diagnostic and/or therapeutic reasons * Signed declaration of consent Exclusion Criteria: * Withdrawal or cessation of participation

Locations (1)

Medical University of Vienna

Vienna, Austria

RECRUITING

Outcomes

Primary Outcomes

To assess and compare the concentration of various cytokines and PD1-lymphoytes in malignant and benign pleural effusions

Time frame: 12 months

Data from ClinicalTrials.gov

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