AssesSment of Early-deteCtion basEd oN liquiD Biopsy in Hepatobiliary Cancer Malignancies

Inclusion Criteria for All the Participants: * 40-75 years old * Ability to comply with study procedures * Ability to provide a written informed consent Exclusion Criteria for All the Participants: * Pregnancy or lactating women * Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant * Recipients of blood transfusion within 7 days prior to study blood draw * Recipients of anti-microbial therapy within 14 days prior to study blood draw * Recipients of any anti-cancer therapy within 30 days prior to study blood draw, due to diseases other than cancer Inclusion Criteria for Cancer Arm Participants: * Confirmed diagnosis or highly suspicious cases of hepatobiliary malignancies * No prior or ongoing anti-cancer therapy (local or systematic) prior to study blood draw Exclusion Criteria for Cancer Arm Participants: * Current diagnosis of other malignancies or multiple primary tumors * Diagnosis of benign diseases by histopathological assessments * Inability to characterize whether the lesion is malignant or benign * Prior or ongoing treatment of cancer Inclusion Criteria for Benign Diseases Arm Participants: * Confirmed diagnosis of benign diseases of the hepatobiliary system * No prior radical treatment of the benign diseases prior to study blood draw Exclusion Criteria for Benign Diseases Arm Participants: * Current or history of malignancies or precancerous lesions * No confirmed diagnosis or inability to characterize a benign disease