the aim of our study is to enhance the dissolution and subsequently the local penetration of the drug through the sulcus in addition to controlling the drug release so that, the drug could be potentially absorbed.
Patients will be divided randomly into three groups: Group (I);will be treated with subgingival debridement and subgengival injection of chitosan 2% gel containing a microsponges formulated (SV), Group (II); will be treated with subgingival debridement and subgingival injection of chitosan 2% gel containing free (SV) and Group (III); will be treated by subgingival debridement and placebo gel injected subgingivally. Pocket depth and clinical attachment loss bone gain were recorded preoperative and six months postoperative for all groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
24
After the reevaluation phase after that corrective surgical phase started for the three groups. Local infiltration anesthesia administrated then sulcular flaps raised for the purpose of open flap subgingival debridement.Randomization was then performed and concealment from the assessors.
Group (I); injected subgingivally with chitosan 2% gel containing a microsponges formulated drug weekly
Group (II); injected subgingivally with chitosan 2% gel containing free drug weekly
Assiut University
Asyut, Egypt
Pocket depth
Will be measured in millimetre
Time frame: Before the beginning of study
Pocket depth
Will be measured in millimetre
Time frame: By the end of study after 6 months of 6 months
Clinical attachment loss
Will be measured in millimetre
Time frame: Before beginning of the study
Clinical attachment loss
Will be measured in millimetre
Time frame: By the end of study after 6 months of 6 months
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Group (III); injected subgingivally with placebo chitosan 2% gel weekly