Double Filtration Plasmapheresis Combined With Chemotherapy

Inclusion Criteria: * Multiple myeloma patients who are diagnosed by bone marrow morphology and immunology * Patients with stable condition after conventional treatment * Patients with renal insufficiency or abnormal M protein * Patients over 18 years of age * Liver function: blood bilirubin ≤ 35μmol/L, enzymes aspartate transaminase (AST)/aka alanine aminotransferase (ALT) is less than 2 times the upper limit of normal * Normal heart function * Physical condition score 0-2 level (ECOG score) * Obtain an informed consent form signed by the patient or family member Exclusion Criteria: * Allergies or obvious contraindications to any of the drugs involved in the plan * Severe heart disease, including myocardial infarction and cardiac insufficiency. * Suffering from other organ malignancies * Active tuberculosis patients and HIV-positive patients * At the same time suffering from other blood system diseases * Pregnant or lactating women * Able to understand or follow the research plan * Past history of intolerance or allergy to similar drugs * Patients under 18 years of age * Participating in other clinical researchers at the same time * There are any other circumstances that hinder the progress of the research