Catheter Ablation of Ventricular Arrhythmia Reduces Skin Sympathetic Activity

Mayo Clinic30 enrolled

Overview

This study is being done to determine whether there is an increase in sympathetic nerve activity before the onset of ventricular arrhythmias or irregular heartbeat rhythm. In addition, this study is looking at the relationship between sympathetic nerve activity and how patients with ventricular arrhythmias respond to catheter ablation treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ventricular Tachycardia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who have non-sustained or sustained VA (VA ≥ 30s or receiving appropriate ICD therapies) are presented to the clinic or admitted to the hospital within 7 days of episodes. * The causes of VA are associated with structural heart diseases including ischemic or nonischemic cardiomyopathy (idiopathic cardiomyopathy, hypertrophic cardiomyopathy, cardiac sarcoidosis or amyloidosis, and arrhythmogentic right ventricular dysplasia). * Subjects are 18 years of age and older. Exclusion Criteria: * Female patients who is pregnant or of childbearing potential and not on a reliable form of birth control. * Allergic to skin patch electrodes. * Vulnerable populations (fetuses, neonates, pregnant women, prisoners, institutionalized individuals).

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Change in amplitude of skin sympathetic nerve activity

measured in µV

Time frame: Baseline, 24 hours post catheter ablation and approximately 3-6 months post-operative

Change in LF/HF ratio

low frequency (LF)/high frequency (HF) ratio of the skin sympathetic nerve activity

Time frame: Baseline, 24 hours post catheter ablation and approximately 3-6 months post-operative

Data from ClinicalTrials.gov

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