An Ultrasound Imaging Technique to Measure Tumors in People With Pancreatic Ductal Adenocarcinoma (PDAC) or Gastrointestinal (GI) Adenocarcinoma

N/AActive Not RecruitingNCT04837833

Memorial Sloan Kettering Cancer Center19 enrolled

Overview

The purpose of this study is to see if ultrasound images that are analyzed by a special computer program can be used to measure the size of PDAC tumors in the liver as accurately as CT scans that involve contrast material (also called contrast-enhanced CT scans). All participants in this study will have pancreatic ductal adenocarcinoma (PDAC) that has spread (metastasized) to the liver, and all participants will be scheduled for a routine CT scan that will measure their cancer.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Pancreas Cancer Gastrointestinal Adenocarcinoma

Interventions

Participants will undergo research ultrasound (rUS1) within three days of their routine CECT scan. A subset of participants (up to 10) will undergo a second research US (rUS2) at 3-4 weeks after rUS1 and at least one month prior to the next planned clinical CECT

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male and female patients, 18 years of age or older * Confirmed diagnosis of PDAC or GI tract adenocarcinoma metastatic to liver * Scheduled for imaging with contrast enhanced CT Exclusion Criteria: * Inability to tolerate intravenous contrast medium * All liver metastases ≤ 10 mm in maximal diameter on the contrast enhanced CT used for comparison to the planned research ultrasound * Multiple confluent liver metastases or tumor burden \> 50% of the liver as estimated by a radiologist

Outcomes

Primary Outcomes

measurement differences between ultrasound tumor volumes

Measure the range of volumetric changes of liver metastases observed between rUS1 and rUS2. We will correlate the rate (%) of tumor volumetric change between the rUS1 and rUS2 to the rate of change between the two CECT.

Time frame: 1 year