This retrospective cohort study aims to characterise outcomes for patients treated on an intensive care unit (ICU) with COVID-19 in England and Wales, one year after discharge from hospital. Outcomes will be compared with patients admitted as an emergency to an ICU for other conditions. The study will use existing national audit data linked to routine healthcare datasets.
Across England and Wales, over 10,000 patients have been treated for severe coronavirus disease 2019 (COVID-19) on an intensive care unit. Around 60% survived to leave hospital. It is unknown how survivors' severe COVID-19 infection, or the treatment they received on the intensive care unit, will affect their long-term health. Understanding what happens to these patients can help ensure they receive suitable care from their General Practitioner (GP) and other National Health Service (NHS) services after they leave hospital. This study will follow up survivors for 1 year after discharge from hospital. The investigators will use data collected by the Intensive Care National Audit and Research Centre (ICNARC) to identify patients who were treated on an ICU for COVID-19. The investigators will then use NHS data to see whether these patients were readmitted to hospital and why. Information from the Office of National Statistics will identify whether patients died. By linking different sources of patient data, the investigators will estimate the health risks faced by survivors of severe COVID-19. These risks will be compared to those in patients treated on an ICU for other conditions.
Study Type
OBSERVATIONAL
Enrollment
319,600
Not applicable as observational study.
Critical Care Research Group, Nuffield Department of Clinical Neurosciences, University of Oxford
Oxford, Oxfordshire, United Kingdom
Mortality Rate
Mortality after discharge from hospital
Time frame: One year
Rate of emergency hospital admission
Emergency hospital admission
Time frame: one year
Rate of emergency hospital admission for respiratory infection
Emergency hospital admission for respiratory infection
Time frame: one year
Rate of emergency hospital admission for a major adverse cardiac event
Emergency hospital admission for a major adverse cardiac event (myocardial infarction, stroke, heart failure)
Time frame: one year
Rate of emergency hospital admission for a venous thrombotic event
Emergency hospital admission for a venous thrombotic event (deep vein thrombosis or pulmonary embolism)
Time frame: one year
Rate of development of end stage renal failure
Development of end stage renal failure treated by renal replacement therapy
Time frame: one year
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