Serum creatinine kinase (CK) level varies with age, gender, race and physical activity. For these reasons there is no normal serum CK level. Many pathological situations cause hyperCKemia, such as neuromuscular disorders (muscular dystrophy, inflammatory myositis, mitochondrial myopathy) and multiple systemic causes. The diagnostic approach to pauci or asymtomatic hyperCKemia can therefore be difficult and lead to multiple, and sometimes invasive tests, such as muscle biopsy. This study aims to describe the diagnoses associated with persistent elevation of serum creatine kinase and to precise the role of the muscule biopsy.
Study Type
OBSERVATIONAL
Enrollment
148
retrospective descriptive without intervention
CHRU Nancy
Nancy, France
Diagnosis
The final diagnosis, as written in the medical record at the end of the investigations in the ward of internal medicin, responsible for the elevation of creatine kinase between: inflammatory myositis, mitochondrial myopathy, muscular dystrophy, non neuromuscular pathology
Time frame: at the end of all investigations, an average of 12 months
Muscle biopsy
Among the patients who underwent a muscle biopsy, number of anormal biopsies that contributed to make the final diagnosis responsible of the elevation of creatine kinase
Time frame: at the end of all investigations, an average of 12 months
Clinical presentation
association between the initial clinical presentation and the final diagnosis
Time frame: at the end of all investigations, an average of 12 months
Paraclinical presentation
association between the initial paraclinical presentation and the final diagnosis
Time frame: at the end of all investigations, an average of 12 months
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