Ruxolitinib With Calcineurin Inhibitor and Methotrexate vs. Calcineurin Inhibitor Plus Methotrexate and Mycophenolate Mofetil as Graft Versus Host Disease Prophylaxis for HLA-haploidentical Hematopoietic Stem Cell Transplantation

Inclusion Criteria: 1. Patients must be diagnosed with malignant hematological disease. 2. aged 12-70 years. 3. Received HLA-haploidentical hematopoietic stem cell transplantation. 4. received myeloablative conditioning 5. Karnofsky score ≥70. 6. creatinine clearance ≥60 mL/min (according to the Cockcroft-Gault formula). (7) liver and kidney function: aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 × upper limit of the normal range (ULN), total bilirubin ≤ 2 × ULN; serum creatinine ≤ 1.5 × ULN. 8\) left ventricular ejection fraction (LVEF) ≥ 50% on echocardiography (ECHO). 9) life expectancy \>12 weeks. 10) Voluntarily signed the consent form and could understand and comply with the requirements of the study. Exclusion Criteria: 1. Active autoimmune disease, such as SLE, rheumatoid arthritis, etc. 2. Current clinically significant active cardiovascular disease such as uncontrolled arrhythmia, uncontrolled hypertension, congestive heart failure, any grade 3 or 4 heart disease as determined by New York Heart Association (NYHA) functional class, or a history of myocardial infarction within 6 months prior to enrollment. 3. Other serious medical conditions that may limit the patient's participation in this trial (e.g., progressive infection, uncontrolled diabetes). 4. human immunodeficiency virus (HIV) infection. 5. cirrhosis of the liver, active hepatitis. 6. Pregnant or lactating women. 7. Patients who are concurrently enrolled in any clinical trials of similar drugs.