Depression appears to be resistant to the available pharmacological treatments. Autonomic responses accompanied by any psychological stress are sympathetic nervous system (SNS) and neuroendocrine responses are formed by hypothalamus-pituitary-adrenal (HPA) axis. The purpose of this study is; assessment of effectiveness of osteopathic approach on sympathetic nervous system and HPA axis in adolescents with depression.
Depression diagnosed and volunteer to participate 39 cases who between the ages of 15-21 included. All participants were recruited and randomly assigned into two groups, the osteopathy group (OG) and the placebo group (PG). Stimulation on the sympathetic truncus and prevertebral ganglia were performed in the OG group. The stimulation of the PG group was performed with a lighter touch and a shorter duration in similar areas. Each participant was filled in the demographic data form, Beck Depression Scale and State and Trait Anxiety Inventory (STAI Form - 1 and Form - 2) before the application. Emotional state visual analog scale and STAI Form - 1 was filled and blood pressure and pulse measurement were made and saliva sample was taken before application, immediately after application and 20 minutes after application.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
39
Treatments that harmonize at the sympathetic nerves or plexus, e.g., sympathetic trunk stimulation by means of the rib-raise technique or stimulation of the prevertebral ganglia.
Different location, size and time of the rib-raise technique or stimulation of the prevertebral ganglia.
Sivas Cumhuriyet University
Sivas, Turkey (Türkiye)
The Beck Depression Inventory (BDI)
The Beck Depression Inventory (BDI) is a 21-item, self-report rating inventory that measures characteristic attitudes and symptoms of depression.
Time frame: Before intervention
The State-Trait Anxiety Inventory (STAI) Form - 1
The State-Trait Anxiety Inventory (STAI) is a commonly used measure of trait and state anxiety. It can be used in clinical settings to diagnose anxiety and to distinguish it from depressive syndromes. It also is often used in research as an indicator of caregiver distress.
Time frame: Before intervention
Change from Baseline The State-Trait Anxiety Inventory (STAI) Form - 2 at 20 minutes
The State-Trait Anxiety Inventory (STAI) is a commonly used measure of trait and state anxiety. It can be used in clinical settings to diagnose anxiety and to distinguish it from depressive syndromes. It also is often used in research as an indicator of caregiver distress.
Time frame: Before intervention, immediately after the intervention, 20 minutes after the intervention
Change from Baseline Heart rate and blood pressure measurements at 20 minutes
Heart rate (beats per minute) and blood pressure (mm/Hg) were measured with automatic blood pressure monitor (the Microlife BP 3BT0-A). It is a clinically validated and 1-star automatic blood pressure monitor
Time frame: Before intervention, immediately after the intervention, 20 minutes after the intervention
Change from Baseline Salivary Biomarkers at 20 minutes
Salivary a-amylase and cortisol levels were measured for each sample. These biomarkers were analysed Enzyme-Linked Immunosorbent Assay.
Time frame: Before intervention, immediately after the intervention, 20 second after the intervention
Demographic data
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Sex; male or female
Time frame: Before intervention
Demographic data
Age; years
Time frame: Before intervention
Demographic data
Height (m); weight (kg); body mass index (kg/m2)
Time frame: Before intervention