Personalizing Window of Implantation During Frozen Embryo Transfer

Clinique Ovo120 enrolled

Overview

Embryo implantation is a crucial event in the establishment of a pregnancy. Although the clinical and culture conditions to obtain a "good quality" embryo are well advanced today, endometrial receptivity remains a major barrier in assisted reproductive techniques. Once a high-quality embryo is transferred, impaired uterine receptivity is believed to be one of the major reasons behind failure of the establishment of pregnancy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

120

Conditions

Fertility

Interventions

AdhesioRTDIAGNOSTIC_TEST

AdhesioRT, a novel diagnostic genetic assay, developed by ovo R\&D scientists, helps to predict the endometrial receptivity and embryo implantation.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women between the ages of 18 to 40 inclusive at the time of oocyte retrieval * Prescription of a single frozen embryo transfer - substituted cycle protocol * Participant has at least 2 vitrified good quality blastocysts Exclusion Criteria: * Women undergoing fertility preservation * Stage IV severe endometriosis * Severe malformation, adenomyosis or uterine anomaly including fibroids deforming the uterine cavity ≥ 5 cm * Positive results of screening for either participant or partner for HIV antibodies, Hepatitis B (other than surface antibodies present after vaccination) or Hepatitis C

Locations (1)

Clinique Ovo

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

Determination of appropriate window of implantation

Comparison between standard frozen embryo transfer and personalized frozen embryo transfer using AdhesioRT to determine a successful window of implantation

Time frame: 14 days after embryo transfer

Secondary Outcomes

Rate of clinical pregnancy

Blood test to determine if the embryo transfer was successful or not

Time frame: 14 days after embryo transfer

Data from ClinicalTrials.gov

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