Clinical Study on PET Imaging, Distribution and PK of 89Zr-CD147 in Patients With Solid Tumors

Inclusion Criteria: 1. Patients must be between 18 and 70 years old (including 18 and 70 years old), male or female; 2. Patients with advanced solid tumors (stage IV): non-small cell lung cancer (NSCLC); Gastric adenocarcinoma; Colorectal adenocarcinoma, etc ; 3. Patients must have an ECOG performance status of 0-1; 4. Patients must have a life expectancy ≥ 12 weeks; 5. Patients must have adequate organ function: White blood cell (WBC) count≥4.0x10\^9/L or absolute neutrophil count (ANC) ≥1.5 x 10\^9/L, Platelets ≥100 x 10\^9/L, Hemoglobin≥ 90g/L ; thrombin time or Activated partial thromboplastin time≤1.5ULN; liver and renal function: Total bilirubin≤1.5ULN (upper limit of normal), Alanine aminotransferase (ALT) or aspartate aminotransferase (AST)≤2.5ULN or ≤5ULN (subjects with liver metastasis), alkaline phosphatase (ALP)≤ 2.5ULN (if there is bone metastasis or liver metastasis ALP≤4.5ULN). Urea (BUN)≤1.5ULN, creatinine≤1.5ULN; 6. Patients must have ≥1 measurable lesion according to RECIST1.1 criteria; 7. For patients who have partners of childbearing potential: Partner and/or patient must use a method of birth control with adequate barrier protection, deemed acceptable by the principle investigator during the study and for 6 months after last study drug administration.; 8. Patients must have the ability to understand and sign an approved ICF. Exclusion Criteria: 1. There are any of the following conditions, such as brain metastasis (except for asymptomatic primary or metastatic brain tumors that do not need treatment), carcinomatous meningitis, myocardial infarction (within 6 months before enrollment), unstable angina pectoris, or high risk of uncontrollable arrhythmia, coronary artery bypass grafting, cerebrovascular accident (within 6 months before enrollment), congestive heart failure (cardiac function grade III-IV), pulmonary embolism, deep venous thrombosis, Infections that need to be treated with intravenous antibiotics within 2 weeks, and immunosuppressant therapy after organ transplantation; 2. Primary central nervous system tumor; 3. HBV DNA≥1000 copies/ml; 4. HCV-RNA≥1000 copies/ml; 5. People with positive antibodies to HIV or syphilis; 6. Patients with acute or subacute intestinal obstruction, or a history of inflammatory bowel disease; 7. Women who are pregnant, breastfeeding or planning pregnancy; 8. People who are known to be allergic to the study preparation or its auxiliary materials; 9. People with a history of psychotropic substance abuse and inability to get rid of it or mental disorders; 10. Patients who cannot lie for half an hour; 11. Patients who are allergic to any component of the imaging agent or antibody; 12. Patients who cannot accept PET/CT imaging; 13. Situations that other researchers consider unsuitable to participate in the trial.