Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation

N/AActive Not RecruitingNCT04842591

Medical University of Graz60 enrolled

Overview

The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pulmonary Hypertension Kidney Transplantation Haemodialysis

Interventions

exercise echocardiographyDIAGNOSTIC_TEST

All patients will undergo exercise echocardiography during a symptom-limited cardiopulmonary exercise test.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age: ≥ 18 years * patients listed for first kidney transplantation at the Clinical Division of Nephrology Exclusion Criteria: * Age \< 18 years * combined organ transplantations (heart-kidney, pancreas-kidney etc.) * patients with prior kidney transplantation * high calcium score on cardiac-CT (\> 160 Agatston Score)

Locations (1)

Medical University of Graz, Department of Internal Medicine, Division of Pulmonology

Graz, Austria

Outcomes

Primary Outcomes

Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope

Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope (calculated as the difference of maximal and resting SPAP divided by the difference of maximal and resting CO) before versus one year after kidney transplantation assessed by exercise echocardiography