Analysis of miRNA Expression in Endometrial Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna150 enrolled

Overview

The TCGA project identified four distinct prognostic groups of endometrial carcinoma (EC) based on molecular alterations: (i) the ultramutated subtype that encompasses POLE mutated (POLE) cases; (ii) the hypermutated subtype, characterized by MisMatch Repair deficiency (MMRd); (iii) the copy-number high subtype, with p53 abnormal/mutated features (p53abn); (iv) the copy-number low subtype, known as No Specific Molecular Profile (NSMP). Although the prognostic value of TCGA molecular classification, NSMP carcinomas present a wide variability in molecular alterations and biological aggressiveness. Given that the study aims to evaluate the miRNA expression profile to identify novel potential biomarkers to better stratify the EC patients, taking into account the molecular status

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Endometrial Cancer

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age\>18yo * histological diagnosis of endometrial cancer * tumor resection * patient's informed consent Exclusion Criteria: * patients with other neoplasia within the last 5 years

Locations (1)

IRCCS- Azienda Ospedaliera-Universitaria di Bologna

Bologna, Bo, Italy

Outcomes

Primary Outcomes

Evaluation of miRNA expression based on the 4 molecular groups

Evaluate miRNA expression based on the 4 molecular groups recently identified

Time frame: 1 year

Secondary Outcomes

Integration of molecular results with clinico-pathological data